The apolipoprotein E2 isoform is associated with accelerated onset of Coronary Artery Disease in Systemic Lupus Erythematosus

Antonio Orlacchio, Ian N. Bruce, Proton Rahman, Toshitaka Kawarai, Giorgio Bernardi, Peter H. St George-Hyslop, Dafna D. Gladman, Murray B. Urowitz

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: Systemic lupus erythematosus (SLE) is a highly prevalent autoimmune disease and coronary artery disease (CAD) is a complication of SLE which is often crucial for the patient's prognosis. It is hypothesized that apolipoprotein E (Apo E), which is involved in cholesterol metabolism, might play a role in this process. Material/Methods: Patients with SLE registered at the University of Toronto Lupus Clinic who had DNA available for study had their Apo E genotype determined. Each case was assessed for the presence of CAD, and Apo E allele frequencies in patients with SLE were compared with data from the general population. Age at onset and disease duration of CAD were also recorded and compared between groups. Results: DNA was stored from 152 patients, of whom 38 (25%) had CAD. There was no difference in the frequencies of the Apo E isoforms between SLE patients and the general population. Patients with the E2 allele developed CAD after a mean ±SD of 6.0±1.9 yrs compared with 14.5±5.4 yrs in those with E3/3 (p
    Original languageEnglish
    Pages (from-to)CR233-CR237
    JournalMedical Science Monitor
    Volume14
    Issue number5
    Publication statusPublished - May 2008

    Keywords

    • Apolipoprotein E
    • Coronary artery disease
    • Systemic lupus erythematosus

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