The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced MRI-The MOST study

Frank W. Roemer, David T. Felson, Tianzhong Yang, Jingbo Niu, Michel D. Crema, Martin Englund, Michael C. Nevitt, Yuqing Zhang, John A. Lynch, George Y. El Khoury, James Torner, Cora E. Lewis, Ali Guermazi

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective: Synovitis is thought to be a secondary phenomenon in the osteoarthritis (OA) process and the menisci might be triggers of localized synovitis. The aim was to assess the cross-sectional associations of posterior horn meniscal damage with perimeniscal synovitis, and with synovitis posterior to the posterior cruciate ligament (PCL) using contrast enhanced (CE) MRI. Design: The Multicenter Osteoarthritis (MOST) Study is a longitudinal observational study of subjects with or at risk for knee OA. Subjects are a subset of MOST who were examined with 1.5. T CE MRI and had semiquantitative synovitis (scored from 0 to 2 at 11 locations) and meniscal readings (scored with WORMS from 0 to 4) available. Logistic regression was used to assess the association of posterior meniscal damage and perimeniscal synovitis in the same compartment, and between posterior meniscal damage and synovitis posterior to the PCL. Results: Three hundred and seventy seven knees were included (mean age 61.1 years±6.9, mean BMI 29.6±4.9, 44.3% women). The odds for ipsi-compartmental perimeniscal synovitis were increased for knees with medial posterior horn meniscal damage (adjusted odds ratio [aOR] 2.5, 95% confidence intervals [95% CI] 1.3,4.8), but not for lateral damage (aOR 1.7, 95% CI 0.4,6.6). No positive associations were found for meniscal damage and presence of synovitis posterior to the PCL (aOR 0.9, 95% CI 0.6,1.5). C: onclusionsMeniscal damage of the posterior horns is associated with ipsi-compartmental perimensical synovitis. No associations were found for posterior horn meniscal damage with synovitis posterior to the PCL, which suggests that synovitis posterior to the PCL is likely to be triggered by different pathomechanisms. © 2013 Elsevier Inc.
    Original languageEnglish
    Pages (from-to)573-581
    Number of pages8
    JournalSeminars in arthritis and rheumatism
    Volume42
    Issue number6
    DOIs
    Publication statusPublished - Jun 2013

    Keywords

    • Magnetic resonance imaging
    • Meniscal damage
    • Osteoarthritis
    • Synovitis

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