The association of donor vasoactive drugs with pancreas transplant graft survival

Introduction •Vasoactive drugs (VaD) are commonly used to correct abnormal haemodynamics of organ donors in Intensive Care Units (ICU). •VaDs can differentially affect insulin secretion positively (dobutamine) or negatively (noradrenaline). Aim •We hypothesised that some VaDs might induce beta-cell stress/death and be associated with adverse pancreas transplant outcomes. •We aimed to assess relationships of VaD use to pancreas transplant graft survival. Methods Results •We used Cox-regression in UK Transplant registry data (2004-2016) to assess associations between use of five VaDs and covariate-adjusted pancreas graft survival (median follow-up: 3 years) before and after correction for multiple testing (p-value threshold: <0.01).