The bacterial skin microbiome in psoriatic arthritis, an unexplored link in pathogenesis: Challenges and opportunities offered by recent technological advances

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The resident microbial community, harboured by humans in sites such as the skin and gastrointestinal tract, is enormous, representing a candidate environmental factor affecting susceptibility to complex diseases, where both genetic and environmental risk factors are important. The potential of microorganisms to influence the human immune system is considerable, given their ubiquity. The impact of the host-gene-microbe interaction on the maintenance of health and the development of disease has not yet been assessed robustly in chronic inflammatory conditions. PsA represents a model inflammatory disease to explore the role of the microbiome because skin involvement and overlap with IBD implicates both the skin and gastrointestinal tract as sources of microbial triggers for PsA. In parallel with genetic studies, characterization of the host microbiota may benefit our understanding of the microbial contribution to disease pathogenesis-knowledge that may eventually inform the development of novel therapeutics. © The Author 2013. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
    Original languageEnglish
    Article numberket319
    Pages (from-to)777-784
    Number of pages7
    JournalRheumatology
    Volume53
    Issue number5
    Early online date24 Sept 2013
    DOIs
    Publication statusPublished - 2014

    Keywords

    • Metagenomics
    • Next-generation sequencing
    • Psoriatic arthritis
    • Skin microbiome

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