The beta1 subunit of the Ca2+-sensitive K+ channel protects against hypertension.

MT Nelson; A. Bonev

The beta1 subunit of the Ca2+-sensitive K+ channel protects against hypertension.

Research output: Contribution to journal › Article › peer-review

Abstract

Previous animal studies have demonstrated that the loss of the beta(1) subunit of the large-conductance Ca(2+)-activated K(+) (BK) channel leads to hypertension. A new study demonstrates that a gain in beta(1) subunit function is associated with protection against diastolic hypertension in humans, underscoring the importance of the beta(1) subunit and the BK channel in the regulation of vascular resistance.

Original language	English
Journal	Journal of Clinical Investigation
Volume	113( 7)
Publication status	Published - Apr 2004

Keywords

Humans
genetics: Hypertension
Large-Conductance Calcium-Activated Potassium Channels
genetics: Potassium Channels, Calcium-Activated
genetics: Protein Subunits
genetics: Vascular Resistance

Cite this

@article{b3ed71fc05dd4148adea06ced8e9c539,

title = "The beta1 subunit of the Ca2+-sensitive K+ channel protects against hypertension.",

abstract = "Previous animal studies have demonstrated that the loss of the beta(1) subunit of the large-conductance Ca(2+)-activated K(+) (BK) channel leads to hypertension. A new study demonstrates that a gain in beta(1) subunit function is associated with protection against diastolic hypertension in humans, underscoring the importance of the beta(1) subunit and the BK channel in the regulation of vascular resistance.",

keywords = "Humans, genetics: Hypertension, Large-Conductance Calcium-Activated Potassium Channels, genetics: Potassium Channels, Calcium-Activated, genetics: Protein Subunits, genetics: Vascular Resistance",

author = "MT Nelson and A. Bonev",

year = "2004",

month = apr,

language = "English",

volume = "113( 7)",

journal = "Journal of Clinical Investigation",

issn = "1558-8238",

publisher = "American Society for Clinical Investigation",

}

TY - JOUR

T1 - The beta1 subunit of the Ca2+-sensitive K+ channel protects against hypertension.

AU - Nelson, MT

AU - Bonev, A.

PY - 2004/4

Y1 - 2004/4

N2 - Previous animal studies have demonstrated that the loss of the beta(1) subunit of the large-conductance Ca(2+)-activated K(+) (BK) channel leads to hypertension. A new study demonstrates that a gain in beta(1) subunit function is associated with protection against diastolic hypertension in humans, underscoring the importance of the beta(1) subunit and the BK channel in the regulation of vascular resistance.

AB - Previous animal studies have demonstrated that the loss of the beta(1) subunit of the large-conductance Ca(2+)-activated K(+) (BK) channel leads to hypertension. A new study demonstrates that a gain in beta(1) subunit function is associated with protection against diastolic hypertension in humans, underscoring the importance of the beta(1) subunit and the BK channel in the regulation of vascular resistance.

KW - Humans

KW - genetics: Hypertension

KW - Large-Conductance Calcium-Activated Potassium Channels

KW - genetics: Potassium Channels, Calcium-Activated

KW - genetics: Protein Subunits

KW - genetics: Vascular Resistance

M3 - Article

SN - 1558-8238

VL - 113( 7)

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

ER -

The beta1 subunit of the Ca2+-sensitive K+ channel protects against hypertension.

Abstract

Keywords

Fingerprint

Cite this