The Bg/II polymorphism of the human prolactin gene lies within intron C and can be detected by PCR/RFLP

F R Stevens, A Hajeer, S John, W Thomson, J Worthington, Julian Davis, W E Ollier

Research output: Contribution to journalArticlepeer-review

Abstract

Prolactin has been shown to be active as an immunomodulatory hormone and is therefore of potential importance in disease progression and development. Any polymorphism in the gene and regulatory sequences may prove useful for disease association studies. A Bg/II polymorphism has been previously detected within the prolactin gene region. We have mapped this polymorphism to intron C and detected the base mutation that causes it. We have also developed a PCR-RFLP method to genotype individuals.

Original languageEnglish
Pages (from-to)261-263
Number of pages3
JournalEuropean Journal of Immunogenetics
Volume26
Issue number4
Publication statusPublished - Aug 1999

Keywords

  • Alleles
  • Bacterial Proteins
  • Base Sequence
  • Chromosomes, Human, Pair 6
  • Deoxyribonucleases, Type II Site-Specific
  • Genotype
  • Humans
  • Introns
  • Models, Genetic
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Polymorphism, Restriction Fragment Length
  • Prolactin
  • Journal Article

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