The birth and postnatal development of purinergic signalling

G. Burnstock, B. B. Fredholm, R. A. North, A. Verkhratsky

Research output: Contribution to journalArticlepeer-review


The purinergic signalling system is one of the most ancient and arguably the most widespread intercellular signalling system in living tissues. In this review we present a detailed account of the early developments and current status of purinergic signalling. We summarize the current knowledge on purinoceptors, their distribution and role in signal transduction in various tissues in physiological and pathophysiological conditions. © 2010 Scandinavian Physiological Society.
Original languageEnglish
Pages (from-to)93-147
Number of pages54
JournalActa Physiologica
Issue number2
Publication statusPublished - Jun 2010


  • Adenosine
  • ATP
  • Co-transmission
  • History
  • Purinergic signalling
  • Purinoceptors


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