The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill

A. L C La Corte; Angela M. Carter; Anthony J. Turner; Peter J. Grant; Nigel M. Hooper

doi:9/4/221 [pii] 10.1177/1470320308096405

The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill

A. L C La Corte, Angela M. Carter, Anthony J. Turner, Peter J. Grant, Nigel M. Hooper

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction. The renin-angiotensin and kininogen-kinin hormonal systems are critically involved in regulating blood pressure and are candidates in contributing to oral contraceptive pill (OCP)-induced hypertension.Angiotensin-converting enzyme (ACE) and aminopeptidase P (AP-P) are key enzymes in these systems and are both involved in the degradation of the vasodilator bradykinin. Methods. Circulating ACE and AP-P levels were measured by activity assay using selective fluorogenic peptide substrates in plasma samples from the Leeds Family Study. In addition, the effect of progesterone on the expression of AP-P and ACE was examined in cells. Results. Women on the OCP had higher age-adjusted plasma AP-P (mean [95% confidence interval]) (0.27 [0.23-0.32] nmol/min/ml (n = 53)) compared with women not on the OCP (0.17 [0.16-0.19] nmol/min/ml (n = 133), p <0.001) or males (0.19 [0.17-0.20] nmol/min/ml (n = 209), p

Original language	English
Pages (from-to)	221-225
Number of pages	4
Journal	JRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Volume	9
Issue number	4
DOIs	https://doi.org/9/4/221 [pii] 10.1177/1470320308096405
Publication status	Published - 2008

Keywords

Aminopeptidase
Blood pressure
Oral contraceptive pill

Research Beacons, Institutes and Platforms

Dementia@Manchester

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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9/4/221 [pii] 10.1177/1470320308096405

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19126663

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title = "The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill",

abstract = "Introduction. The renin-angiotensin and kininogen-kinin hormonal systems are critically involved in regulating blood pressure and are candidates in contributing to oral contraceptive pill (OCP)-induced hypertension.Angiotensin-converting enzyme (ACE) and aminopeptidase P (AP-P) are key enzymes in these systems and are both involved in the degradation of the vasodilator bradykinin. Methods. Circulating ACE and AP-P levels were measured by activity assay using selective fluorogenic peptide substrates in plasma samples from the Leeds Family Study. In addition, the effect of progesterone on the expression of AP-P and ACE was examined in cells. Results. Women on the OCP had higher age-adjusted plasma AP-P (mean [95% confidence interval]) (0.27 [0.23-0.32] nmol/min/ml (n = 53)) compared with women not on the OCP (0.17 [0.16-0.19] nmol/min/ml (n = 133), p <0.001) or males (0.19 [0.17-0.20] nmol/min/ml (n = 209), p",

keywords = "Aminopeptidase, Blood pressure, Oral contraceptive pill",

author = "{La Corte}, {A. L C} and Carter, {Angela M.} and Turner, {Anthony J.} and Grant, {Peter J.} and Hooper, {Nigel M.}",

note = "La Corte, Amy L Cilia Carter, Angela M Turner, Anthony J Grant, Peter J Hooper, Nigel M England Journal of the renin-angiotensin-aldosterone system : JRAAS J Renin Angiotensin Aldosterone Syst. 2008 Dec;9(4):221-5.",

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T1 - The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill

AU - La Corte, A. L C

AU - Carter, Angela M.

AU - Turner, Anthony J.

AU - Grant, Peter J.

AU - Hooper, Nigel M.

N1 - La Corte, Amy L Cilia Carter, Angela M Turner, Anthony J Grant, Peter J Hooper, Nigel M England Journal of the renin-angiotensin-aldosterone system : JRAAS J Renin Angiotensin Aldosterone Syst. 2008 Dec;9(4):221-5.

PY - 2008

Y1 - 2008

N2 - Introduction. The renin-angiotensin and kininogen-kinin hormonal systems are critically involved in regulating blood pressure and are candidates in contributing to oral contraceptive pill (OCP)-induced hypertension.Angiotensin-converting enzyme (ACE) and aminopeptidase P (AP-P) are key enzymes in these systems and are both involved in the degradation of the vasodilator bradykinin. Methods. Circulating ACE and AP-P levels were measured by activity assay using selective fluorogenic peptide substrates in plasma samples from the Leeds Family Study. In addition, the effect of progesterone on the expression of AP-P and ACE was examined in cells. Results. Women on the OCP had higher age-adjusted plasma AP-P (mean [95% confidence interval]) (0.27 [0.23-0.32] nmol/min/ml (n = 53)) compared with women not on the OCP (0.17 [0.16-0.19] nmol/min/ml (n = 133), p <0.001) or males (0.19 [0.17-0.20] nmol/min/ml (n = 209), p

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JO - JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

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The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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