TY - JOUR
T1 - The Burden and Impact of Cough in Patients with Idiopathic Pulmonary Fibrosis
T2 - An Analysis of the Prospective Observational PROFILE Study
AU - Saunders, Peter
AU - Wu, Zhe
AU - Fahy, William A
AU - Stewart, Iain D
AU - Saini, Gauri
AU - Smith, David J F
AU - Braybrooke, Rebecca
AU - Stock, Carmel
AU - Renzoni, Elisabetta A
AU - Johnson, Simon R
AU - Jenkins, R Gisli
AU - Belvisi, Maria G
AU - Smith, Jaclyn A
AU - Maher, Toby M
AU - Molyneaux, Philip L
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Rationale: Cough is a commonly reported symptom in idiopathic pulmonary fibrosis (IPF) that negatively impacts patient-reported quality of life (QoL). However, both the burden of cough at diagnosis and the behavior of cough over time have not been systematically described in patients with IPF. Objectives: By utilizing data prospectively collected as part of the PROFILE study, we sought to assess cough burden and the impact that this has on QoL within a cohort of patients with newly diagnosed IPF. We also reexamined the previously described relationship between cough and mortality and the association of cough with the MUC5B promoter polymorphism. Methods: The PROFILE study is a multicenter, prospective, observational, longitudinal cohort study of incident IPF. Scores on the Leicester Cough Questionnaire (LCQ) were recorded at baseline in 632 subjects and then repeated 6 monthly in a subset (n = 216) of the cohort. Results: The median LCQ score at diagnosis was 16.1 (interquartile range, 6.5). LCQ scores remained stable over the subsequent year in the majority of patients. There was a weak association between LCQ score and baseline lung function, with worse cough-related QoL associated with more severe physiological impairment. Cough scores were not associated with subsequent mortality after correcting for baseline lung function. Furthermore, there was no relationship between LCQ score and MUC5B promoter polymorphism status. Conclusions: The burden of cough in IPF is high. Although cough is weakly associated with disease severity at baseline, cough-specific QoL, as measured by the LCQ, confers no prognostic value. Cough-specific QoL burden remains relatively stable over time and does not associate with MUC5B promoter polymorphism.
AB - Rationale: Cough is a commonly reported symptom in idiopathic pulmonary fibrosis (IPF) that negatively impacts patient-reported quality of life (QoL). However, both the burden of cough at diagnosis and the behavior of cough over time have not been systematically described in patients with IPF. Objectives: By utilizing data prospectively collected as part of the PROFILE study, we sought to assess cough burden and the impact that this has on QoL within a cohort of patients with newly diagnosed IPF. We also reexamined the previously described relationship between cough and mortality and the association of cough with the MUC5B promoter polymorphism. Methods: The PROFILE study is a multicenter, prospective, observational, longitudinal cohort study of incident IPF. Scores on the Leicester Cough Questionnaire (LCQ) were recorded at baseline in 632 subjects and then repeated 6 monthly in a subset (n = 216) of the cohort. Results: The median LCQ score at diagnosis was 16.1 (interquartile range, 6.5). LCQ scores remained stable over the subsequent year in the majority of patients. There was a weak association between LCQ score and baseline lung function, with worse cough-related QoL associated with more severe physiological impairment. Cough scores were not associated with subsequent mortality after correcting for baseline lung function. Furthermore, there was no relationship between LCQ score and MUC5B promoter polymorphism status. Conclusions: The burden of cough in IPF is high. Although cough is weakly associated with disease severity at baseline, cough-specific QoL, as measured by the LCQ, confers no prognostic value. Cough-specific QoL burden remains relatively stable over time and does not associate with MUC5B promoter polymorphism.
KW - MUC5B
KW - cough
KW - interstitial lung disease
KW - quality of life
UR - http://www.scopus.com/inward/record.url?scp=85169503174&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/1d965225-b753-3aa4-8045-2dfec33ccafe/
U2 - 10.1513/AnnalsATS.202302-174OC
DO - 10.1513/AnnalsATS.202302-174OC
M3 - Article
C2 - 37159951
SN - 2325-6621
VL - 20
SP - 1267
EP - 1273
JO - Annals of the American Thoracic Society
JF - Annals of the American Thoracic Society
IS - 9
ER -