The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts.

Louise Fleming; Clare Murray; Aruna T Bansal; Simone Hashimoto; Hans Bisgaard; Andrew Bush; Urs Frey; Gunilla Hedlin; Florian Singer; Wim M van Aalderen; Nadja H Vissing; Zaraquiza Zolkipli; Anna Selby; Stephen Fowler; Dominick Shaw; Kian Fan Chung; Ana R Sousa; Scott Wagers; Julie Corfield; Ioannis Pandis; Anthony Rowe; Elena Formaggio; Peter J Sterk; Graham Roberts

doi:10.1183/13993003.00780-2015

The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts.

Louise Fleming, Clare Murray, Aruna T Bansal, Simone Hashimoto, Hans Bisgaard, Andrew Bush, Urs Frey, Gunilla Hedlin, Florian Singer, Wim M van Aalderen, Nadja H Vissing, Zaraquiza Zolkipli, Anna Selby, Stephen Fowler, Dominick Shaw, Kian Fan Chung, Ana R Sousa, Scott Wagers, Julie Corfield, Ioannis PandisAnthony Rowe, Elena Formaggio, Peter J Sterk, Graham Roberts

Research output: Contribution to journal › Article › peer-review

Abstract

U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches.A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 school-age children with mild/moderate asthma and 53 preschoolers with mild/moderate wheeze in a cross-sectional study.Despite high-dose treatment, the severe cohorts had more severe exacerbations compared with the mild/moderate ones (annual medians: school-aged 3.0 versus 1.1, preschool 3.9 versus 1.8; p

Original language	English
Journal	The European respiratory journal
Volume	46
Issue number	5
DOIs	https://doi.org/10.1183/13993003.00780-2015
Publication status	Published - Nov 2015

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Fleming, L., Murray, C., Bansal, A. T., Hashimoto, S., Bisgaard, H., Bush, A., Frey, U., Hedlin, G., Singer, F., van Aalderen, W. M., Vissing, N. H., Zolkipli, Z., Selby, A., Fowler, S., Shaw, D., Chung, K. F., Sousa, A. R., Wagers, S., Corfield, J., ... Roberts, G. (2015). The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts. The European respiratory journal, 46(5). https://doi.org/10.1183/13993003.00780-2015

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title = "The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts.",

abstract = "U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches.A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 school-age children with mild/moderate asthma and 53 preschoolers with mild/moderate wheeze in a cross-sectional study.Despite high-dose treatment, the severe cohorts had more severe exacerbations compared with the mild/moderate ones (annual medians: school-aged 3.0 versus 1.1, preschool 3.9 versus 1.8; p",

author = "Louise Fleming and Clare Murray and Bansal, {Aruna T} and Simone Hashimoto and Hans Bisgaard and Andrew Bush and Urs Frey and Gunilla Hedlin and Florian Singer and {van Aalderen}, {Wim M} and Vissing, {Nadja H} and Zaraquiza Zolkipli and Anna Selby and Stephen Fowler and Dominick Shaw and Chung, {Kian Fan} and Sousa, {Ana R} and Scott Wagers and Julie Corfield and Ioannis Pandis and Anthony Rowe and Elena Formaggio and Sterk, {Peter J} and Graham Roberts",

year = "2015",

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doi = "10.1183/13993003.00780-2015",

language = "English",

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journal = "The European respiratory journal",

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Fleming, L, Murray, C, Bansal, AT, Hashimoto, S, Bisgaard, H, Bush, A, Frey, U, Hedlin, G, Singer, F, van Aalderen, WM, Vissing, NH, Zolkipli, Z, Selby, A, Fowler, S, Shaw, D, Chung, KF, Sousa, AR, Wagers, S, Corfield, J, Pandis, I, Rowe, A, Formaggio, E, Sterk, PJ & Roberts, G 2015, 'The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts.', The European respiratory journal, vol. 46, no. 5. https://doi.org/10.1183/13993003.00780-2015

TY - JOUR

T1 - The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts.

AU - Fleming, Louise

AU - Murray, Clare

AU - Bansal, Aruna T

AU - Hashimoto, Simone

AU - Bisgaard, Hans

AU - Bush, Andrew

AU - Frey, Urs

AU - Hedlin, Gunilla

AU - Singer, Florian

AU - van Aalderen, Wim M

AU - Vissing, Nadja H

AU - Zolkipli, Zaraquiza

AU - Selby, Anna

AU - Fowler, Stephen

AU - Shaw, Dominick

AU - Chung, Kian Fan

AU - Sousa, Ana R

AU - Wagers, Scott

AU - Corfield, Julie

AU - Pandis, Ioannis

AU - Rowe, Anthony

AU - Formaggio, Elena

AU - Sterk, Peter J

AU - Roberts, Graham

PY - 2015/11

Y1 - 2015/11

N2 - U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches.A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 school-age children with mild/moderate asthma and 53 preschoolers with mild/moderate wheeze in a cross-sectional study.Despite high-dose treatment, the severe cohorts had more severe exacerbations compared with the mild/moderate ones (annual medians: school-aged 3.0 versus 1.1, preschool 3.9 versus 1.8; p

AB - U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches.A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 school-age children with mild/moderate asthma and 53 preschoolers with mild/moderate wheeze in a cross-sectional study.Despite high-dose treatment, the severe cohorts had more severe exacerbations compared with the mild/moderate ones (annual medians: school-aged 3.0 versus 1.1, preschool 3.9 versus 1.8; p

U2 - 10.1183/13993003.00780-2015

DO - 10.1183/13993003.00780-2015

M3 - Article

C2 - 26405287

SN - 0903-1936

VL - 46

JO - The European respiratory journal

JF - The European respiratory journal

IS - 5

ER -

The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts.

Abstract

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