The cellular biology of tendon grafting

Nasra Alam, D. A. McGrouther, J. K F Wong

Research output: Contribution to journalArticlepeer-review


We investigated the cellular biology of tendon grafting in a mouse model using green fluorescent protein mismatch grafting and quantitative immunohistochemistry of molecular markers for inflammation, proliferation, collagen synthesis, cell death, and myofibroblast/pericyte expression. We provide a detailed analysis of the healing characteristics during the phases of inflammation, synthesis, and remodelling. Our findings indicated that survival of the cells in the grafted tendon was finite. Syngenic and autologous grafts provoked a similar cellular reaction and all grafts healed. Cells in the graft contributed significantly to collagen synthesis and do have a role in healing. © The Author(s) 2013.
Original languageEnglish
Pages (from-to)79-92
Number of pages13
JournalJournal of Hand Surgery: European Volume
Issue number1
Publication statusPublished - 8 Jan 2013


  • apoptosis
  • collagen synthesis
  • grafting
  • inflammation
  • mouse
  • proliferation
  • Tendon
  • vascularization


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