The characterization of protein post-translational modifications by mass spectrometry

Claire Eyers, Rebecca E. Schweppe, Claire E. Haydon, Timothy S. Lewis, Katheryn A. Resing, Natalie G. Ahn

    Research output: Contribution to journalArticlepeer-review


    Most biological processes are regulated by post-translational modifications of proteins, and conditions that disrupt the regulation of such events can lead to disease, In the past decade, the identification and characterization of covalent modifications have been driven by advances in mass spectrometry. Here, we discuss current mass spectrometric and proteomic approaches for the identification of proteins and their covalent modifications, and we highlight high-throughput strategies for comprehensive analysis of cell proteomes.
    Original languageEnglish
    Pages (from-to)453-461
    Number of pages8
    JournalAccounts of Chemical Research
    Issue number6
    Publication statusPublished - 1 Jun 2003


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