The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum

S. Bowman; D. Lawson; D. Basham; D. Brown; T. Chillingworth; C. M. Churcher; A. Craig; R. M. Davies; K. Devlin; T. Feltwell; S. Gentles; R. Gwilliam; N. Hamlin; D. Harris; S. Holroyd; T. Hornsby; P. Horrocks; K. Jagels; B. Jassal; S. Kyes; J. McLean; S. Moule; K. Mungall; L. Murphy; K. Oliver; M. A. Quail; M. A. Rajandream; S. Rutter; J. Skelton; R. Squares; S. Squares; J. E. Sulston; S. Whitehead; J. R. Woodward; C. Newbold; B. G. Barrell

doi:10.1038/22964

The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum

S. Bowman, D. Lawson, D. Basham, D. Brown, T. Chillingworth, C. M. Churcher, A. Craig, R. M. Davies, K. Devlin, T. Feltwell, S. Gentles, R. Gwilliam, N. Hamlin, D. Harris, S. Holroyd, T. Hornsby, P. Horrocks, K. Jagels, B. Jassal, S. KyesJ. McLean, S. Moule, K. Mungall, L. Murphy, K. Oliver, M. A. Quail, M. A. Rajandream, S. Rutter, J. Skelton, R. Squares, S. Squares, J. E. Sulston, S. Whitehead, J. R. Woodward, C. Newbold, B. G. Barrell

Research output: Contribution to journal › Article › peer-review

Abstract

Analysis of Plasmodium falciparum chromosome 3, and comparison with chromosome 2, highlights novel features of chromosome organization and gene structure. The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function. A putative centromere has been identified that has a core region of about 2 kilobases with an extremely high (adenine + thymidine) composition and arrays of tandem repeats. We have predicted 215 protein-coding genes and two transfer RNA genes in the 1,060,106-base-pair chromosome sequence. The predicted protein- coding genes can be divided into three main classes: 52.6% are not spliced, 45.1% have a large exon with short additional 5' or 3' exons, and 2.3% have a multiple exon structure more typical of higher eukaryotes.

Original language	English
Pages (from-to)	532-538
Number of pages	6
Journal	Nature
Volume	400
Issue number	6744
DOIs	https://doi.org/10.1038/22964
Publication status	Published - 5 Aug 1999

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Bowman, S., Lawson, D., Basham, D., Brown, D., Chillingworth, T., Churcher, C. M., Craig, A., Davies, R. M., Devlin, K., Feltwell, T., Gentles, S., Gwilliam, R., Hamlin, N., Harris, D., Holroyd, S., Hornsby, T., Horrocks, P., Jagels, K., Jassal, B., ... Barrell, B. G. (1999). The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Nature, 400(6744), 532-538. https://doi.org/10.1038/22964

@article{00605fde960b4f8eb3b8839ee0bc1d3d,

title = "The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum",

abstract = "Analysis of Plasmodium falciparum chromosome 3, and comparison with chromosome 2, highlights novel features of chromosome organization and gene structure. The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function. A putative centromere has been identified that has a core region of about 2 kilobases with an extremely high (adenine + thymidine) composition and arrays of tandem repeats. We have predicted 215 protein-coding genes and two transfer RNA genes in the 1,060,106-base-pair chromosome sequence. The predicted protein- coding genes can be divided into three main classes: 52.6% are not spliced, 45.1% have a large exon with short additional 5' or 3' exons, and 2.3% have a multiple exon structure more typical of higher eukaryotes.",

author = "S. Bowman and D. Lawson and D. Basham and D. Brown and T. Chillingworth and Churcher, {C. M.} and A. Craig and Davies, {R. M.} and K. Devlin and T. Feltwell and S. Gentles and R. Gwilliam and N. Hamlin and D. Harris and S. Holroyd and T. Hornsby and P. Horrocks and K. Jagels and B. Jassal and S. Kyes and J. McLean and S. Moule and K. Mungall and L. Murphy and K. Oliver and Quail, {M. A.} and Rajandream, {M. A.} and S. Rutter and J. Skelton and R. Squares and S. Squares and Sulston, {J. E.} and S. Whitehead and Woodward, {J. R.} and C. Newbold and Barrell, {B. G.}",

year = "1999",

month = aug,

day = "5",

doi = "10.1038/22964",

language = "English",

volume = "400",

pages = "532--538",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "6744",

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Bowman, S, Lawson, D, Basham, D, Brown, D, Chillingworth, T, Churcher, CM, Craig, A, Davies, RM, Devlin, K, Feltwell, T, Gentles, S, Gwilliam, R, Hamlin, N, Harris, D, Holroyd, S, Hornsby, T, Horrocks, P, Jagels, K, Jassal, B, Kyes, S, McLean, J, Moule, S, Mungall, K, Murphy, L, Oliver, K, Quail, MA, Rajandream, MA, Rutter, S, Skelton, J, Squares, R, Squares, S, Sulston, JE, Whitehead, S, Woodward, JR, Newbold, C & Barrell, BG 1999, 'The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum', Nature, vol. 400, no. 6744, pp. 532-538. https://doi.org/10.1038/22964

TY - JOUR

T1 - The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum

AU - Bowman, S.

AU - Lawson, D.

AU - Basham, D.

AU - Brown, D.

AU - Chillingworth, T.

AU - Churcher, C. M.

AU - Craig, A.

AU - Davies, R. M.

AU - Devlin, K.

AU - Feltwell, T.

AU - Gentles, S.

AU - Gwilliam, R.

AU - Hamlin, N.

AU - Harris, D.

AU - Holroyd, S.

AU - Hornsby, T.

AU - Horrocks, P.

AU - Jagels, K.

AU - Jassal, B.

AU - Kyes, S.

AU - McLean, J.

AU - Moule, S.

AU - Mungall, K.

AU - Murphy, L.

AU - Oliver, K.

AU - Quail, M. A.

AU - Rajandream, M. A.

AU - Rutter, S.

AU - Skelton, J.

AU - Squares, R.

AU - Squares, S.

AU - Sulston, J. E.

AU - Whitehead, S.

AU - Woodward, J. R.

AU - Newbold, C.

AU - Barrell, B. G.

PY - 1999/8/5

Y1 - 1999/8/5

N2 - Analysis of Plasmodium falciparum chromosome 3, and comparison with chromosome 2, highlights novel features of chromosome organization and gene structure. The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function. A putative centromere has been identified that has a core region of about 2 kilobases with an extremely high (adenine + thymidine) composition and arrays of tandem repeats. We have predicted 215 protein-coding genes and two transfer RNA genes in the 1,060,106-base-pair chromosome sequence. The predicted protein- coding genes can be divided into three main classes: 52.6% are not spliced, 45.1% have a large exon with short additional 5' or 3' exons, and 2.3% have a multiple exon structure more typical of higher eukaryotes.

AB - Analysis of Plasmodium falciparum chromosome 3, and comparison with chromosome 2, highlights novel features of chromosome organization and gene structure. The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function. A putative centromere has been identified that has a core region of about 2 kilobases with an extremely high (adenine + thymidine) composition and arrays of tandem repeats. We have predicted 215 protein-coding genes and two transfer RNA genes in the 1,060,106-base-pair chromosome sequence. The predicted protein- coding genes can be divided into three main classes: 52.6% are not spliced, 45.1% have a large exon with short additional 5' or 3' exons, and 2.3% have a multiple exon structure more typical of higher eukaryotes.

U2 - 10.1038/22964

DO - 10.1038/22964

M3 - Article

C2 - 10448855

SN - 0028-0836

VL - 400

SP - 532

EP - 538

JO - Nature

JF - Nature

IS - 6744

ER -

The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum

Abstract

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