The CONNECT project: Combining macro- and micro-structure

Yaniv Assaf; Daniel C. Alexander; Derek K. Jones; Albero Bizzi; Tim E J Behrens; Chris A. Clark; Yoram Cohen; Tim B. Dyrby; Petra S. Huppi; Thomas R. Knoesche; Denis LeBihan; Geoff J M Parker; Cyril Poupon; Debbie Anaby; Alfred Anwander; Leah Bar; Daniel Barazany; Tamar Blumenfeld-Katzir; Silvia De-Santis; Delphine Duclap; Matteo Figini; Elda Fischi; Pamela Guevara; Penny Hubbard; Shir Hofstetter; Saad Jbabdi; Nicolas Kunz; Francois Lazeyras; Alice Lebois; Matthew G. Liptrot; Henrik Lundell; Jean Franc Mangin cedil;ois; David Moreno Dominguez; Darya Morozov; Jan Schreiber; Kiran Seunarine; Simone Nava; Till Riffert; Efrat Sasson; Benoit Schmitt; Noam Shemesh; Stam N. Sotiropoulos; Ido Tavor; Hui Zhang; Feng Lei Zhou

doi:10.1016/j.neuroimage.2013.05.055

The CONNECT project: Combining macro- and micro-structure

Yaniv Assaf, Daniel C. Alexander, Derek K. Jones, Albero Bizzi, Tim E J Behrens, Chris A. Clark, Yoram Cohen, Tim B. Dyrby, Petra S. Huppi, Thomas R. Knoesche, Denis LeBihan, Geoff J M Parker, Cyril Poupon, Debbie Anaby, Alfred Anwander, Leah Bar, Daniel Barazany, Tamar Blumenfeld-Katzir, Silvia De-Santis, Delphine DuclapMatteo Figini, Elda Fischi, Pamela Guevara, Penny Hubbard, Shir Hofstetter, Saad Jbabdi, Nicolas Kunz, Francois Lazeyras, Alice Lebois, Matthew G. Liptrot, Henrik Lundell, Jean Franc Mangin cedil;ois, David Moreno Dominguez, Darya Morozov, Jan Schreiber, Kiran Seunarine, Simone Nava, Till Riffert, Efrat Sasson, Benoit Schmitt, Noam Shemesh, Stam N. Sotiropoulos, Ido Tavor, Hui Zhang, Feng Lei Zhou

Research output: Contribution to journal › Article › peer-review

Abstract

In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states.The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome. © 2013 Elsevier Inc.

Original language	English
Pages (from-to)	273-282
Number of pages	9
Journal	NeuroImage
Volume	80
DOIs	https://doi.org/10.1016/j.neuroimage.2013.05.055
Publication status	Published - 15 Oct 2013

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Assaf, Y., Alexander, D. C., Jones, D. K., Bizzi, A., Behrens, T. E. J., Clark, C. A., Cohen, Y., Dyrby, T. B., Huppi, P. S., Knoesche, T. R., LeBihan, D., Parker, G. J. M., Poupon, C., Anaby, D., Anwander, A., Bar, L., Barazany, D., Blumenfeld-Katzir, T., De-Santis, S., ... Zhou, F. L. (2013). The CONNECT project: Combining macro- and micro-structure. NeuroImage, 80, 273-282. https://doi.org/10.1016/j.neuroimage.2013.05.055

@article{0e0a65e2e3ca4bf7ab97623b3998fc7a,

title = "The CONNECT project: Combining macro- and micro-structure",

abstract = "In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states.The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome. {\textcopyright} 2013 Elsevier Inc.",

author = "Yaniv Assaf and Alexander, {Daniel C.} and Jones, {Derek K.} and Albero Bizzi and Behrens, {Tim E J} and Clark, {Chris A.} and Yoram Cohen and Dyrby, {Tim B.} and Huppi, {Petra S.} and Knoesche, {Thomas R.} and Denis LeBihan and Parker, {Geoff J M} and Cyril Poupon and Debbie Anaby and Alfred Anwander and Leah Bar and Daniel Barazany and Tamar Blumenfeld-Katzir and Silvia De-Santis and Delphine Duclap and Matteo Figini and Elda Fischi and Pamela Guevara and Penny Hubbard and Shir Hofstetter and Saad Jbabdi and Nicolas Kunz and Francois Lazeyras and Alice Lebois and Liptrot, {Matthew G.} and Henrik Lundell and {Mangin cedil;ois}, {Jean Franc} and Dominguez, {David Moreno} and Darya Morozov and Jan Schreiber and Kiran Seunarine and Simone Nava and Till Riffert and Efrat Sasson and Benoit Schmitt and Noam Shemesh and Sotiropoulos, {Stam N.} and Ido Tavor and Hui Zhang and Zhou, {Feng Lei}",

year = "2013",

month = oct,

day = "15",

doi = "10.1016/j.neuroimage.2013.05.055",

language = "English",

volume = "80",

pages = "273--282",

journal = "NeuroImage",

issn = "1053-8119",

publisher = "Elsevier BV",

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Assaf, Y, Alexander, DC, Jones, DK, Bizzi, A, Behrens, TEJ, Clark, CA, Cohen, Y, Dyrby, TB, Huppi, PS, Knoesche, TR, LeBihan, D, Parker, GJM, Poupon, C, Anaby, D, Anwander, A, Bar, L, Barazany, D, Blumenfeld-Katzir, T, De-Santis, S, Duclap, D, Figini, M, Fischi, E, Guevara, P, Hubbard, P, Hofstetter, S, Jbabdi, S, Kunz, N, Lazeyras, F, Lebois, A, Liptrot, MG, Lundell, H, Mangin cedil;ois, JF, Dominguez, DM, Morozov, D, Schreiber, J, Seunarine, K, Nava, S, Riffert, T, Sasson, E, Schmitt, B, Shemesh, N, Sotiropoulos, SN, Tavor, I, Zhang, H & Zhou, FL 2013, 'The CONNECT project: Combining macro- and micro-structure', NeuroImage, vol. 80, pp. 273-282. https://doi.org/10.1016/j.neuroimage.2013.05.055

TY - JOUR

T1 - The CONNECT project: Combining macro- and micro-structure

AU - Assaf, Yaniv

AU - Alexander, Daniel C.

AU - Jones, Derek K.

AU - Bizzi, Albero

AU - Behrens, Tim E J

AU - Clark, Chris A.

AU - Cohen, Yoram

AU - Dyrby, Tim B.

AU - Huppi, Petra S.

AU - Knoesche, Thomas R.

AU - LeBihan, Denis

AU - Parker, Geoff J M

AU - Poupon, Cyril

AU - Anaby, Debbie

AU - Anwander, Alfred

AU - Bar, Leah

AU - Barazany, Daniel

AU - Blumenfeld-Katzir, Tamar

AU - De-Santis, Silvia

AU - Duclap, Delphine

AU - Figini, Matteo

AU - Fischi, Elda

AU - Guevara, Pamela

AU - Hubbard, Penny

AU - Hofstetter, Shir

AU - Jbabdi, Saad

AU - Kunz, Nicolas

AU - Lazeyras, Francois

AU - Lebois, Alice

AU - Liptrot, Matthew G.

AU - Lundell, Henrik

AU - Mangin cedil;ois, Jean Franc

AU - Dominguez, David Moreno

AU - Morozov, Darya

AU - Schreiber, Jan

AU - Seunarine, Kiran

AU - Nava, Simone

AU - Riffert, Till

AU - Sasson, Efrat

AU - Schmitt, Benoit

AU - Shemesh, Noam

AU - Sotiropoulos, Stam N.

AU - Tavor, Ido

AU - Zhang, Hui

AU - Zhou, Feng Lei

PY - 2013/10/15

Y1 - 2013/10/15

N2 - In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states.The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome. © 2013 Elsevier Inc.

AB - In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states.The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome. © 2013 Elsevier Inc.

U2 - 10.1016/j.neuroimage.2013.05.055

DO - 10.1016/j.neuroimage.2013.05.055

M3 - Article

SN - 1053-8119

VL - 80

SP - 273

EP - 282

JO - NeuroImage

JF - NeuroImage

ER -

The CONNECT project: Combining macro- and micro-structure

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