The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)

S. M. McKenna; P. Mines; P. Law; K. Kovacs-Schreiner; W. R. Birmingham; N. J. Turner; S. Leimkühler; A. J. Carnell

doi:10.1039/c7gc01696d

The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)

S. M. McKenna, P. Mines, P. Law, K. Kovacs-Schreiner, W. R. Birmingham, N. J. Turner, S. Leimkühler, A. J. Carnell^*

^*Corresponding author for this work

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Abstract

By manipulating the reaction conditions, furandicarboxylic acid (FDCA) was prepared by the biooxidation of hydroxymethyl furfural (HMF) in a continuous one-pot reaction using galactose oxidase M_3-5, periplasmic aldehyde oxidase (PaoABC), catalase and horseradish peroxidase. In addition, PaoABC was successfully entrapped in a SiO₂ hydrogel and recycled 14 times without loss of activity. The catalyst was able to tolerate up to 200 mM DFF concentration giving FDCA in full conversion with very promising TOF and TON values.

Original language	English
Pages (from-to)	4660-4665
Number of pages	6
Journal	Green Chemistry
Volume	19
Issue number	19
Early online date	23 Aug 2017
DOIs	https://doi.org/10.1039/c7gc01696d
Publication status	Published - 2017

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title = "The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)",

abstract = "By manipulating the reaction conditions, furandicarboxylic acid (FDCA) was prepared by the biooxidation of hydroxymethyl furfural (HMF) in a continuous one-pot reaction using galactose oxidase M3-5, periplasmic aldehyde oxidase (PaoABC), catalase and horseradish peroxidase. In addition, PaoABC was successfully entrapped in a SiO2 hydrogel and recycled 14 times without loss of activity. The catalyst was able to tolerate up to 200 mM DFF concentration giving FDCA in full conversion with very promising TOF and TON values.",

author = "McKenna, {S. M.} and P. Mines and P. Law and K. Kovacs-Schreiner and Birmingham, {W. R.} and Turner, {N. J.} and S. Leimk{\"u}hler and Carnell, {A. J.}",

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T1 - The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)

AU - McKenna, S. M.

AU - Mines, P.

AU - Law, P.

AU - Kovacs-Schreiner, K.

AU - Birmingham, W. R.

AU - Turner, N. J.

AU - Leimkühler, S.

AU - Carnell, A. J.

PY - 2017

Y1 - 2017

N2 - By manipulating the reaction conditions, furandicarboxylic acid (FDCA) was prepared by the biooxidation of hydroxymethyl furfural (HMF) in a continuous one-pot reaction using galactose oxidase M3-5, periplasmic aldehyde oxidase (PaoABC), catalase and horseradish peroxidase. In addition, PaoABC was successfully entrapped in a SiO2 hydrogel and recycled 14 times without loss of activity. The catalyst was able to tolerate up to 200 mM DFF concentration giving FDCA in full conversion with very promising TOF and TON values.

AB - By manipulating the reaction conditions, furandicarboxylic acid (FDCA) was prepared by the biooxidation of hydroxymethyl furfural (HMF) in a continuous one-pot reaction using galactose oxidase M3-5, periplasmic aldehyde oxidase (PaoABC), catalase and horseradish peroxidase. In addition, PaoABC was successfully entrapped in a SiO2 hydrogel and recycled 14 times without loss of activity. The catalyst was able to tolerate up to 200 mM DFF concentration giving FDCA in full conversion with very promising TOF and TON values.

UR - http://www.scopus.com/inward/record.url?scp=85030707793&partnerID=8YFLogxK

U2 - 10.1039/c7gc01696d

DO - 10.1039/c7gc01696d

M3 - Article

AN - SCOPUS:85030707793

SN - 1463-9262

VL - 19

SP - 4660

EP - 4665

JO - Green Chemistry

JF - Green Chemistry

IS - 19

ER -

The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)

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