The cutaneous side-effects of hydroxyurea

Helen Young; H. S. Young; A. S A Khan; J. R. Kendra; I. H. Coulson

doi:10.1046/j.1365-2257.2000.00311.x

The cutaneous side-effects of hydroxyurea

Helen Young, H. S. Young, A. S A Khan, J. R. Kendra, I. H. Coulson

Research output: Contribution to journal › Article › peer-review

Abstract

The cutaneous side-effects of long-term hydroxyurea therapy are not widely known and only rarely reported. We report on a patient who developed widespread skin changes, including the recently recognized hydroxyurea dermopathy, during long-term treatment with hydroxyurea for polycythaemia rubra vera. The time course of the clinical changes suggests that they result from direct toxicity of hydroxyurea on the basal layer of the epidermis and mucosal surfaces. We aim to increase clinical awareness of this problem.

Original language	English
Pages (from-to)	229-232
Number of pages	3
Journal	Clinical and Laboratory Haematology
Volume	22
Issue number	4
DOIs	https://doi.org/10.1046/j.1365-2257.2000.00311.x
Publication status	Published - 2000

Keywords

Hydroxyurea
Hydroxyurea dermopathy
Longitudinal melanonychia
Nonscarring alopecia
Skin malignancy

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10.1046/j.1365-2257.2000.00311.x

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title = "The cutaneous side-effects of hydroxyurea",

abstract = "The cutaneous side-effects of long-term hydroxyurea therapy are not widely known and only rarely reported. We report on a patient who developed widespread skin changes, including the recently recognized hydroxyurea dermopathy, during long-term treatment with hydroxyurea for polycythaemia rubra vera. The time course of the clinical changes suggests that they result from direct toxicity of hydroxyurea on the basal layer of the epidermis and mucosal surfaces. We aim to increase clinical awareness of this problem.",

keywords = "Hydroxyurea, Hydroxyurea dermopathy, Longitudinal melanonychia, Nonscarring alopecia, Skin malignancy",

author = "Helen Young and Young, {H. S.} and Khan, {A. S A} and Kendra, {J. R.} and Coulson, {I. H.}",

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AU - Young, Helen

AU - Young, H. S.

AU - Khan, A. S A

AU - Kendra, J. R.

AU - Coulson, I. H.

PY - 2000

Y1 - 2000

N2 - The cutaneous side-effects of long-term hydroxyurea therapy are not widely known and only rarely reported. We report on a patient who developed widespread skin changes, including the recently recognized hydroxyurea dermopathy, during long-term treatment with hydroxyurea for polycythaemia rubra vera. The time course of the clinical changes suggests that they result from direct toxicity of hydroxyurea on the basal layer of the epidermis and mucosal surfaces. We aim to increase clinical awareness of this problem.

AB - The cutaneous side-effects of long-term hydroxyurea therapy are not widely known and only rarely reported. We report on a patient who developed widespread skin changes, including the recently recognized hydroxyurea dermopathy, during long-term treatment with hydroxyurea for polycythaemia rubra vera. The time course of the clinical changes suggests that they result from direct toxicity of hydroxyurea on the basal layer of the epidermis and mucosal surfaces. We aim to increase clinical awareness of this problem.

KW - Hydroxyurea

KW - Hydroxyurea dermopathy

KW - Longitudinal melanonychia

KW - Nonscarring alopecia

KW - Skin malignancy

U2 - 10.1046/j.1365-2257.2000.00311.x

DO - 10.1046/j.1365-2257.2000.00311.x

M3 - Article

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VL - 22

SP - 229

EP - 232

JO - Clinical and Laboratory Haematology

JF - Clinical and Laboratory Haematology

IS - 4

ER -

The cutaneous side-effects of hydroxyurea

Abstract

Keywords

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