The design and synthesis of novel 3-[2-indol-1-yl-ethyl]-1H-indole derivatives as selective inhibitors of CDK4

Carine Aubry, Asma Patel, Sachin Mahale, Bhabatosh Chaudhuri, Jean Didier Maréchal, Michael J. Sutcliffe, Paul R. Jenkins

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We present the design, synthesis and biological activity of novel 3-[2-indol-1-yl-ethyl]-1H-indole selective inhibitors of CDK4. © 2005 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)1423-1425
    Number of pages2
    JournalTetrahedron Letters
    Volume46
    Issue number9
    DOIs
    Publication statusPublished - 28 Feb 2005

    Keywords

    • 3-[2-Indol-1-yl-ethyl]-1H-indole
    • CDK4
    • Fascaplysin
    • IC50
    • Indole
    • Molecular modelling

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