@article{21a499b8978847bf806658ddb0c9d982,
title = "The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy",
abstract = "Hematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells. This has facilitated the analysis of the vascular microenvironment in steady state and malignant hematopoiesis. In this review, we provide an overview of the bone marrow microenvironment, focusing on refined analyses of the marrow vascular compartment performed in mouse studies. We also discuss the emerging role of the vascular niche in “inflamm-aging” and clonal hematopoiesis, and how the endothelial microenvironment influences, supports and interacts with hematopoietic cells in acute myeloid leukemia and myelodysplastic syndromes, as exemplar states of malignant myelopoiesis. Finally, we provide an overview of strategies for modulating these bidirectional interactions to therapeutic effect in myeloid malignancies.",
keywords = "acute myeloid leukemia, hematopoietic stem cells, myelodysplastic syndromes, targeted therapies, vascular niche",
author = "Laura Mosteo and Joanna Storer and Kiran Batta and Emma Searle and Delfim Duarte and Daniel Wiseman",
note = "Funding Information: Funding. DW and KB are supported by the Oglesby Charitable Trust. DW is additionally supported by a Blood Cancer United Kingdom Clinician Scientist Fellowship (number 15030). LM is supported by a grant from the National Blood Foundation (NBF). JS is supported by a Manchester Cancer Research Centre Studentship. ES is supported by research funding from The Christie Charitable Trust and The Academy of Medical Sciences. DD is funded by NBF, the European Hematology Association (EHA), and Funda??o Am?lia de Mello. Funding Information: DW and KB are supported by the Oglesby Charitable Trust. DW is additionally supported by a Blood Cancer United Kingdom Clinician Scientist Fellowship (number 15030). LM is supported by a grant from the National Blood Foundation (NBF). JS is supported by a Manchester Cancer Research Centre Studentship. ES is supported by research funding from The Christie Charitable Trust and The Academy of Medical Sciences. DD is funded by NBF, the European Hematology Association (EHA), and Funda{\c c}{\~a}o Am{\'e}lia de Mello. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Mosteo, Storer, Batta, Searle, Duarte and Wiseman.",
year = "2021",
month = mar,
day = "11",
doi = "10.3389/fcell.2021.635189",
language = "English",
volume = "9",
journal = "Frontiers in cell and developmental biology",
issn = "2296-6342",
publisher = "Frontiers Media S. A.",
}