The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.

Ratko Djukanović; Tim Harrison; Sebastian Johnston; Flic Gabbay; Peter Wark; Neil C Thomson; Robert Niven; Dave Singh; Helen Reddel; Donna E Davies; Richard Marsden; Christine Boxall; Vincent Plagnol; Stephen T Holgate; Christopher Brightling; Phillip Bardin; Liam Heaney; Lorcan McGarvey; Ian Sabroe; Bernard Higgins; Mark Arya; Christopher Strang; Najib Rahman; Babatunde Oyesile; Hawys Thomas; Essam Hakim; Phillip Monk; Jody Brookes; Sarah Dudley; Rona Beegan; Joanna Samways; INTERCIA Study Group

doi:10.1164/rccm.201312-2235OC

The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.

Ratko Djukanović (Collaborator), Tim Harrison (Collaborator), Sebastian Johnston (Collaborator), Flic Gabbay, Peter Wark (Collaborator), Neil C Thomson (Collaborator), Robert Niven (Collaborator), Dave Singh, Helen Reddel (Collaborator), Donna E Davies (Collaborator), Richard Marsden, Christine Boxall (Collaborator), Vincent Plagnol, Stephen T Holgate (Collaborator), Christopher Brightling (Collaborator), Phillip Bardin (Collaborator), Liam Heaney (Collaborator), Lorcan McGarvey (Collaborator), Ian Sabroe (Collaborator), Bernard Higgins (Collaborator)Mark Arya (Collaborator), Christopher Strang (Collaborator), Najib Rahman (Collaborator), Babatunde Oyesile (Collaborator), Hawys Thomas (Collaborator), Essam Hakim (Collaborator), Phillip Monk (Collaborator), Jody Brookes (Collaborator), Sarah Dudley (Collaborator), Rona Beegan (Collaborator), Joanna Samways (Collaborator), INTERCIA Study Group

Research output: Contribution to journal › Article › peer-review

Abstract

RATIONALE: Ex vivo, bronchial epithelial cells from people with asthma are more susceptible to rhinovirus infection caused by deficient induction of the antiviral protein, IFN-β. Exogenous IFN-β restores antiviral activity. OBJECTIVES: To compare the efficacy and safety of inhaled IFN-β with placebo administered to people with asthma after onset of cold symptoms to prevent or attenuate asthma symptoms caused by respiratory viruses. METHODS: A total of 147 people with asthma on inhaled corticosteroids (British Thoracic Society Steps 2-5), with a history of virus-associated exacerbations, were randomized to 14-day treatment with inhaled IFN-β (n = 72) or placebo (n = 75) within 24 hours of developing cold symptoms and were assessed clinically, with relevant samples collected to assess virus infection and antiviral responses. MEASUREMENTS AND MAIN RESULTS: A total of 91% of randomized patients developed a defined cold. In this modified intention-to-treat population, asthma symptoms did not get clinically significantly worse (mean change in six-item Asthma Control Questionnaire

Original language	English
Pages (from-to)	145-154
Number of pages	9
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	190
Issue number	2
DOIs	https://doi.org/10.1164/rccm.201312-2235OC
Publication status	Published - 15 Jul 2014

Keywords

innate immunity
respiratory virus
treatment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1164/rccm.201312-2235OC

Cite this

Djukanović, R., Harrison, T., Johnston, S., Gabbay, F., Wark, P., Thomson, N. C., Niven, R., Singh, D., Reddel, H., Davies, D. E., Marsden, R., Boxall, C., Plagnol, V., Holgate, S. T., Brightling, C., Bardin, P., Heaney, L., McGarvey, L., Sabroe, I., ... INTERCIA Study Group (2014). The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial. American Journal of Respiratory and Critical Care Medicine, 190(2), 145-154. https://doi.org/10.1164/rccm.201312-2235OC

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title = "The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.",

abstract = "RATIONALE: Ex vivo, bronchial epithelial cells from people with asthma are more susceptible to rhinovirus infection caused by deficient induction of the antiviral protein, IFN-β. Exogenous IFN-β restores antiviral activity. OBJECTIVES: To compare the efficacy and safety of inhaled IFN-β with placebo administered to people with asthma after onset of cold symptoms to prevent or attenuate asthma symptoms caused by respiratory viruses. METHODS: A total of 147 people with asthma on inhaled corticosteroids (British Thoracic Society Steps 2-5), with a history of virus-associated exacerbations, were randomized to 14-day treatment with inhaled IFN-β (n = 72) or placebo (n = 75) within 24 hours of developing cold symptoms and were assessed clinically, with relevant samples collected to assess virus infection and antiviral responses. MEASUREMENTS AND MAIN RESULTS: A total of 91% of randomized patients developed a defined cold. In this modified intention-to-treat population, asthma symptoms did not get clinically significantly worse (mean change in six-item Asthma Control Questionnaire",

keywords = "innate immunity, respiratory virus, treatment",

author = "Ratko Djukanovi{\'c} and Tim Harrison and Sebastian Johnston and Flic Gabbay and Peter Wark and Thomson, {Neil C} and Robert Niven and Dave Singh and Helen Reddel and Davies, {Donna E} and Richard Marsden and Christine Boxall and Vincent Plagnol and Holgate, {Stephen T} and Christopher Brightling and {de Looze}, Ferdinandus and Phillip Bardin and Liam Heaney and Lorcan McGarvey and Ian Sabroe and Bernard Higgins and Mark Arya and Christopher Strang and Najib Rahman and Babatunde Oyesile and Hawys Thomas and Essam Hakim and Phillip Monk and Jody Brookes and Sarah Dudley and Rona Beegan and Joanna Samways and {INTERCIA Study Group}",

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Djukanović, R, Harrison, T, Johnston, S, Gabbay, F, Wark, P, Thomson, NC, Niven, R, Singh, D, Reddel, H, Davies, DE, Marsden, R, Boxall, C, Plagnol, V, Holgate, ST, Brightling, C, Bardin, P, Heaney, L, McGarvey, L, Sabroe, I, Higgins, B, Arya, M, Strang, C, Rahman, N, Oyesile, B, Thomas, H, Hakim, E, Monk, P, Brookes, J, Dudley, S, Beegan, R, Samways, J & INTERCIA Study Group 2014, 'The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.', American Journal of Respiratory and Critical Care Medicine, vol. 190, no. 2, pp. 145-154. https://doi.org/10.1164/rccm.201312-2235OC

The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial. / Djukanović, Ratko (Collaborator); Harrison, Tim (Collaborator); Johnston, Sebastian (Collaborator) et al.
In: American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2, 15.07.2014, p. 145-154.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.

AU - Gabbay, Flic

AU - Singh, Dave

AU - Marsden, Richard

AU - Plagnol, Vincent

AU - INTERCIA Study Group

A2 - Djukanović, Ratko

A2 - Harrison, Tim

A2 - Johnston, Sebastian

A2 - Wark, Peter

A2 - Thomson, Neil C

A2 - Niven, Robert

A2 - Reddel, Helen

A2 - Davies, Donna E

A2 - Boxall, Christine

A2 - Holgate, Stephen T

A2 - Brightling, Christopher

A2 - de Looze, Ferdinandus

A2 - Bardin, Phillip

A2 - Heaney, Liam

A2 - McGarvey, Lorcan

A2 - Sabroe, Ian

A2 - Higgins, Bernard

A2 - Arya, Mark

A2 - Strang, Christopher

A2 - Rahman, Najib

A2 - Oyesile, Babatunde

A2 - Thomas, Hawys

A2 - Hakim, Essam

A2 - Monk, Phillip

A2 - Brookes, Jody

A2 - Dudley, Sarah

A2 - Beegan, Rona

A2 - Samways, Joanna

N1 - G0501506, Medical Research Council, United KingdomG0900453, Medical Research Council, United KingdomG1000758, Medical Research Council, United Kingdom

PY - 2014/7/15

Y1 - 2014/7/15

N2 - RATIONALE: Ex vivo, bronchial epithelial cells from people with asthma are more susceptible to rhinovirus infection caused by deficient induction of the antiviral protein, IFN-β. Exogenous IFN-β restores antiviral activity. OBJECTIVES: To compare the efficacy and safety of inhaled IFN-β with placebo administered to people with asthma after onset of cold symptoms to prevent or attenuate asthma symptoms caused by respiratory viruses. METHODS: A total of 147 people with asthma on inhaled corticosteroids (British Thoracic Society Steps 2-5), with a history of virus-associated exacerbations, were randomized to 14-day treatment with inhaled IFN-β (n = 72) or placebo (n = 75) within 24 hours of developing cold symptoms and were assessed clinically, with relevant samples collected to assess virus infection and antiviral responses. MEASUREMENTS AND MAIN RESULTS: A total of 91% of randomized patients developed a defined cold. In this modified intention-to-treat population, asthma symptoms did not get clinically significantly worse (mean change in six-item Asthma Control Questionnaire

AB - RATIONALE: Ex vivo, bronchial epithelial cells from people with asthma are more susceptible to rhinovirus infection caused by deficient induction of the antiviral protein, IFN-β. Exogenous IFN-β restores antiviral activity. OBJECTIVES: To compare the efficacy and safety of inhaled IFN-β with placebo administered to people with asthma after onset of cold symptoms to prevent or attenuate asthma symptoms caused by respiratory viruses. METHODS: A total of 147 people with asthma on inhaled corticosteroids (British Thoracic Society Steps 2-5), with a history of virus-associated exacerbations, were randomized to 14-day treatment with inhaled IFN-β (n = 72) or placebo (n = 75) within 24 hours of developing cold symptoms and were assessed clinically, with relevant samples collected to assess virus infection and antiviral responses. MEASUREMENTS AND MAIN RESULTS: A total of 91% of randomized patients developed a defined cold. In this modified intention-to-treat population, asthma symptoms did not get clinically significantly worse (mean change in six-item Asthma Control Questionnaire

KW - innate immunity

KW - respiratory virus

KW - treatment

U2 - 10.1164/rccm.201312-2235OC

DO - 10.1164/rccm.201312-2235OC

M3 - Article

C2 - 24937476

SN - 1535-4970

VL - 190

SP - 145

EP - 154

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 2

ER -

The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.

Abstract

Keywords

UN SDGs

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