The Effect of Lutein Supplementation on Blood Plasma Levels of Complement Factor D, C5a and C3d

Yuan Tian; Aize Kijlstra; Rob L P van der Veen; Maria Makridaki; Ian J. Murray; Tos T J M Berendschot

doi:10.1371/journal.pone.0073387

The Effect of Lutein Supplementation on Blood Plasma Levels of Complement Factor D, C5a and C3d

Yuan Tian, Aize Kijlstra, Rob L P van der Veen, Maria Makridaki, Ian J. Murray, Tos T J M Berendschot

Research output: Contribution to journal › Article › peer-review

Abstract

Lutein is selectively taken up by the primate retina and plays an important role as a filter for harmful blue light and as an antioxidant. Recent studies have shown that lutein has systemic anti-inflammatory properties. Dietary lutein has been associated with reduced circulating levels of inflammatory biomarkers such as CRP and sICAM. Whether lutein also affects activation of the complement system has not yet been addressed and was the purpose of the study described here. Seventy-two subjects with signs of early macular degeneration were randomly assigned to receive either a 10 mg lutein supplement or a placebo during one year. EDTA blood samples were collected at 0, 4, 8 and 12 months. Complement factor D (CFD), a rate limiting component of the alternative pathway of complement activation and the complement activation products C5a and C3d were determined in the plasma samples by ELISA. A significant 0.11 μg/ml monthly decrease in plasma CFD concentration was observed in the lutein group (p

Original language	English
Article number	e73387
Journal	PLoS ONE
Volume	8
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0073387
Publication status	Published - 29 Aug 2013

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abstract = "Lutein is selectively taken up by the primate retina and plays an important role as a filter for harmful blue light and as an antioxidant. Recent studies have shown that lutein has systemic anti-inflammatory properties. Dietary lutein has been associated with reduced circulating levels of inflammatory biomarkers such as CRP and sICAM. Whether lutein also affects activation of the complement system has not yet been addressed and was the purpose of the study described here. Seventy-two subjects with signs of early macular degeneration were randomly assigned to receive either a 10 mg lutein supplement or a placebo during one year. EDTA blood samples were collected at 0, 4, 8 and 12 months. Complement factor D (CFD), a rate limiting component of the alternative pathway of complement activation and the complement activation products C5a and C3d were determined in the plasma samples by ELISA. A significant 0.11 μg/ml monthly decrease in plasma CFD concentration was observed in the lutein group (p",

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AU - Murray, Ian J.

AU - Berendschot, Tos T J M

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The Effect of Lutein Supplementation on Blood Plasma Levels of Complement Factor D, C5a and C3d

Abstract

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