The effect of oxytocin infusion on adenohypophyseal function in man

S. R. Page; V. T Y Ang; R. Jackson; A. White; S. S. Nussey; J. S. Jenkins

The effect of oxytocin infusion on adenohypophyseal function in man

S. R. Page, V. T Y Ang, R. Jackson, A. White, S. S. Nussey, J. S. Jenkins

Research output: Contribution to journal › Article › peer-review

Abstract

The responses of the adenohypophyseal hormones adrenocorticotrophin (ACTH), growth hormone (GH), thyroid stimulating hormone (TSH), prolactin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) to sub-maximal doses of hypothalamic releasing factors were studied in six lean male volunteers (age 23-35 years) with and without infusion of oxytocin (OXT). OXT infusion (mean plasma concentration 133.6 ± 2.6 pmol/l) completely inhibited the plasma ACTH responses to corticotrophin releasing hormone (CRH) (saline, peak increment ACTH 1.61 ± 0.75 pmol/l; OXT, peak increment ACTH -0.04 ± 0.28 pmol/l; P <0.05). OXT infusion had no significant effect on the GH response to growth hormone releasing hormone (GHRH), the TSH and prolactin responses to thyrotrophin releasing hormone (thyroliberin, TRH) or the LH and FSH responses to gonadotrophin releasing hormone (luteoliberin, GnRH). The data support a role for OXT in the modulation of ACTH secretion in man.

Original language	English
Pages (from-to)	307-313
Number of pages	6
Journal	Clinical Endocrinology
Volume	32
Issue number	3
Publication status	Published - 1990

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@article{69032d4091e04ee2b76e4c2d85ec8bdf,

title = "The effect of oxytocin infusion on adenohypophyseal function in man",

abstract = "The responses of the adenohypophyseal hormones adrenocorticotrophin (ACTH), growth hormone (GH), thyroid stimulating hormone (TSH), prolactin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) to sub-maximal doses of hypothalamic releasing factors were studied in six lean male volunteers (age 23-35 years) with and without infusion of oxytocin (OXT). OXT infusion (mean plasma concentration 133.6 ± 2.6 pmol/l) completely inhibited the plasma ACTH responses to corticotrophin releasing hormone (CRH) (saline, peak increment ACTH 1.61 ± 0.75 pmol/l; OXT, peak increment ACTH -0.04 ± 0.28 pmol/l; P <0.05). OXT infusion had no significant effect on the GH response to growth hormone releasing hormone (GHRH), the TSH and prolactin responses to thyrotrophin releasing hormone (thyroliberin, TRH) or the LH and FSH responses to gonadotrophin releasing hormone (luteoliberin, GnRH). The data support a role for OXT in the modulation of ACTH secretion in man.",

author = "Page, {S. R.} and Ang, {V. T Y} and R. Jackson and A. White and Nussey, {S. S.} and Jenkins, {J. S.}",

year = "1990",

language = "English",

volume = "32",

pages = "307--313",

journal = "Clinical Endocrinology",

issn = "1365-2265",

publisher = "John Wiley & Sons Ltd",

number = "3",

}

TY - JOUR

T1 - The effect of oxytocin infusion on adenohypophyseal function in man

AU - Page, S. R.

AU - Ang, V. T Y

AU - Jackson, R.

AU - White, A.

AU - Nussey, S. S.

AU - Jenkins, J. S.

PY - 1990

Y1 - 1990

N2 - The responses of the adenohypophyseal hormones adrenocorticotrophin (ACTH), growth hormone (GH), thyroid stimulating hormone (TSH), prolactin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) to sub-maximal doses of hypothalamic releasing factors were studied in six lean male volunteers (age 23-35 years) with and without infusion of oxytocin (OXT). OXT infusion (mean plasma concentration 133.6 ± 2.6 pmol/l) completely inhibited the plasma ACTH responses to corticotrophin releasing hormone (CRH) (saline, peak increment ACTH 1.61 ± 0.75 pmol/l; OXT, peak increment ACTH -0.04 ± 0.28 pmol/l; P <0.05). OXT infusion had no significant effect on the GH response to growth hormone releasing hormone (GHRH), the TSH and prolactin responses to thyrotrophin releasing hormone (thyroliberin, TRH) or the LH and FSH responses to gonadotrophin releasing hormone (luteoliberin, GnRH). The data support a role for OXT in the modulation of ACTH secretion in man.

AB - The responses of the adenohypophyseal hormones adrenocorticotrophin (ACTH), growth hormone (GH), thyroid stimulating hormone (TSH), prolactin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) to sub-maximal doses of hypothalamic releasing factors were studied in six lean male volunteers (age 23-35 years) with and without infusion of oxytocin (OXT). OXT infusion (mean plasma concentration 133.6 ± 2.6 pmol/l) completely inhibited the plasma ACTH responses to corticotrophin releasing hormone (CRH) (saline, peak increment ACTH 1.61 ± 0.75 pmol/l; OXT, peak increment ACTH -0.04 ± 0.28 pmol/l; P <0.05). OXT infusion had no significant effect on the GH response to growth hormone releasing hormone (GHRH), the TSH and prolactin responses to thyrotrophin releasing hormone (thyroliberin, TRH) or the LH and FSH responses to gonadotrophin releasing hormone (luteoliberin, GnRH). The data support a role for OXT in the modulation of ACTH secretion in man.

M3 - Article

SN - 1365-2265

VL - 32

SP - 307

EP - 313

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 3

ER -

The effect of oxytocin infusion on adenohypophyseal function in man

Abstract

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