The effect of pimobendan on left atrial pressure in dogs with mitral valve regurgitation

S Suzuki, R Fukushima, T Ishikawa, L Hamabe, D Aytemiz, H Huai-Che, S Nakao, N Machida, R Tanaka

    Research output: Contribution to journalArticlepeer-review


    BACKGROUND: The effects of pimobendan on left atrial pressure (LAP) in dogs with mitral valve disease (MR) have not been documented in a quantitative manner.

    OBJECTIVE: The objective was to document and study the short-term effects of pimobendan on LAP and echocardiographic parameters in MR dogs.

    ANIMALS: Eight healthy Beagle dogs weighing 10.0-14.7 kg (3 males and 5 females; aged 2 years) were used.

    METHODS: Experimental, cross-over, and interventional study. Dogs with surgically induced MR received pimobendan at either 0.25 mg/kg or 0.50 mg/kg p.o. q12h for 7 days and then, after a 7-day wash-out period, the other dosage. LAP was measured for 30 minutes at baseline and again on days 1, 2, 4, and 7 of pimobendan administration.

    RESULTS: Mean LAP was significantly decreased after the administration of 0.25 mg/kg (15.81 ± 5.44 mmHg to 12.67 ± 5.71 mmHg, P < .001) and 0.50 mg/kg (15.76 ± 5.45 mmHg to 10.77 ± 5.23 mmHg, P < .001). Also, the 0.50 mg/kg group led to a significantly lower LAP (P < .01) compared with the 0.25 mg/kg group. Significant reduction was seen for the first time 4 days after the administration of 0.25 mg/kg and a day after the administration of 0.50 mg/kg.

    CONCLUSIONS AND CLINICAL IMPORTANCE: Pimobendan decreased LAP in a dose-dependent manner in dogs with acute MR caused by experimental chordal rupture. This study did not evaluate adverse effects of high-dose pimobendan, and additional studies in clinical patients are warranted.

    Original languageEnglish
    Pages (from-to)1328-33
    Number of pages6
    JournalJournal of Veterinary Internal Medicine
    Issue number6
    Publication statusPublished - 19 Nov 2011


    • Animals
    • Atrial Function, Left
    • Blood Pressure
    • Cross-Over Studies
    • Dogs
    • Dose-Response Relationship, Drug
    • Echocardiography, Three-Dimensional
    • Female
    • Male
    • Mitral Valve Insufficiency
    • Pyridazines
    • Telemetry
    • Vasodilator Agents


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