The effect of polymeric additives on the solubilisation of a poorly-soluble drug in micellar solutions of Pluronic F127

Cristiane P. Oliveira; Luiz C G Vasconcellos; Maria Elenir N P Ribeiro; Nágila M P S Ricardo; Ticiane V De P Souza; Flávia De M L L Costa; Chiraphon Chaibundit; Stephen G. Yeates; David Attwood

doi:10.1016/j.ijpharm.2011.02.025

The effect of polymeric additives on the solubilisation of a poorly-soluble drug in micellar solutions of Pluronic F127

Cristiane P. Oliveira, Luiz C G Vasconcellos, Maria Elenir N P Ribeiro, Nágila M P S Ricardo, Ticiane V De P Souza, Flávia De M L L Costa, Chiraphon Chaibundit, Stephen G. Yeates, David Attwood

Research output: Contribution to journal › Article › peer-review

Abstract

The solubilisation of griseofulvin in 1 wt% aqueous micellar solutions of Pluronic F127 at 37 °C has been modified by adding polyethylene glycol PEG 35000 or poly(vinylpyrrolidone) PVP K30. The solubilisation capacity expressed in terms of unit weight of F127 is increased by the addition of 0.5 wt% PEG 35000 to a value approaching double that of a 2.5 wt% solution of F127 alone, but there is no advantage in adding 0.5 wt% PVP K30. © 2011 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	206-208
Number of pages	2
Journal	International Journal of Pharmaceutics
Volume	409
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2011.02.025
Publication status	Published - 16 May 2011

Keywords

Micelles
PEG
Pluronic F127
PVP
Solubilisation

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10.1016/j.ijpharm.2011.02.025

Organic Materials Innovation Centre (OMIC)
Michael Turner (Participant), Stephen Yeates (Participant), Colin Booth (Participant), Iain May (Participant), David Collison (Participant), David Procter (Participant) & Andromachi Malandraki (Participant)
Impact: Technological, Economic, Society and culture

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Oliveira, C. P., Vasconcellos, L. C. G., Ribeiro, M. E. N. P., Ricardo, N. M. P. S., Souza, T. V. D. P., Costa, F. D. M. L. L., Chaibundit, C., Yeates, S. G., & Attwood, D. (2011). The effect of polymeric additives on the solubilisation of a poorly-soluble drug in micellar solutions of Pluronic F127. International Journal of Pharmaceutics, 409(1-2), 206-208. https://doi.org/10.1016/j.ijpharm.2011.02.025

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title = "The effect of polymeric additives on the solubilisation of a poorly-soluble drug in micellar solutions of Pluronic F127",

abstract = "The solubilisation of griseofulvin in 1 wt% aqueous micellar solutions of Pluronic F127 at 37 °C has been modified by adding polyethylene glycol PEG 35000 or poly(vinylpyrrolidone) PVP K30. The solubilisation capacity expressed in terms of unit weight of F127 is increased by the addition of 0.5 wt% PEG 35000 to a value approaching double that of a 2.5 wt% solution of F127 alone, but there is no advantage in adding 0.5 wt% PVP K30. {\textcopyright} 2011 Elsevier B.V. All rights reserved.",

keywords = "Micelles, PEG, Pluronic F127, PVP, Solubilisation",

author = "Oliveira, {Cristiane P.} and Vasconcellos, {Luiz C G} and Ribeiro, {Maria Elenir N P} and Ricardo, {N{\'a}gila M P S} and Souza, {Ticiane V De P} and Costa, {Fl{\'a}via De M L L} and Chiraphon Chaibundit and Yeates, {Stephen G.} and David Attwood",

year = "2011",

month = may,

day = "16",

doi = "10.1016/j.ijpharm.2011.02.025",

language = "English",

volume = "409",

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journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier BV",

number = "1-2",

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Oliveira, CP, Vasconcellos, LCG, Ribeiro, MENP, Ricardo, NMPS, Souza, TVDP, Costa, FDMLL, Chaibundit, C, Yeates, SG & Attwood, D 2011, 'The effect of polymeric additives on the solubilisation of a poorly-soluble drug in micellar solutions of Pluronic F127', International Journal of Pharmaceutics, vol. 409, no. 1-2, pp. 206-208. https://doi.org/10.1016/j.ijpharm.2011.02.025

TY - JOUR

T1 - The effect of polymeric additives on the solubilisation of a poorly-soluble drug in micellar solutions of Pluronic F127

AU - Oliveira, Cristiane P.

AU - Vasconcellos, Luiz C G

AU - Ribeiro, Maria Elenir N P

AU - Ricardo, Nágila M P S

AU - Souza, Ticiane V De P

AU - Costa, Flávia De M L L

AU - Chaibundit, Chiraphon

AU - Yeates, Stephen G.

AU - Attwood, David

PY - 2011/5/16

Y1 - 2011/5/16

N2 - The solubilisation of griseofulvin in 1 wt% aqueous micellar solutions of Pluronic F127 at 37 °C has been modified by adding polyethylene glycol PEG 35000 or poly(vinylpyrrolidone) PVP K30. The solubilisation capacity expressed in terms of unit weight of F127 is increased by the addition of 0.5 wt% PEG 35000 to a value approaching double that of a 2.5 wt% solution of F127 alone, but there is no advantage in adding 0.5 wt% PVP K30. © 2011 Elsevier B.V. All rights reserved.

AB - The solubilisation of griseofulvin in 1 wt% aqueous micellar solutions of Pluronic F127 at 37 °C has been modified by adding polyethylene glycol PEG 35000 or poly(vinylpyrrolidone) PVP K30. The solubilisation capacity expressed in terms of unit weight of F127 is increased by the addition of 0.5 wt% PEG 35000 to a value approaching double that of a 2.5 wt% solution of F127 alone, but there is no advantage in adding 0.5 wt% PVP K30. © 2011 Elsevier B.V. All rights reserved.

KW - Micelles

KW - PEG

KW - Pluronic F127

KW - PVP

KW - Solubilisation

U2 - 10.1016/j.ijpharm.2011.02.025

DO - 10.1016/j.ijpharm.2011.02.025

M3 - Article

VL - 409

SP - 206

EP - 208

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

The effect of polymeric additives on the solubilisation of a poorly-soluble drug in micellar solutions of Pluronic F127

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Keywords

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Organic Materials Innovation Centre (OMIC)

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