The effect of reducing the fine-particle mass of salmeterol from metered-dose inhalers on bronchodilatation and bronchoprotection against methacholine challenge: A randomized, placebo-controlled, double-blind, crossover study

David Allen; Barbara McDonnell; Neil Wheeler; Raj K. Sharma; Andrew Sykes; Ashley Woodcock

doi:10.1016/j.clinthera.2005.07.006

The effect of reducing the fine-particle mass of salmeterol from metered-dose inhalers on bronchodilatation and bronchoprotection against methacholine challenge: A randomized, placebo-controlled, double-blind, crossover study

David Allen, Barbara McDonnell, Neil Wheeler, Raj K. Sharma, Andrew Sykes, Ashley Woodcock

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: This study examined the clinical relevance of fine-particle mass (FPM) delivered from metered dose inhalers (MDIs) to bronchodilatation and bronchoprotection against methacholine challenge by comparing a marketed chlorofluorocarbon (CFC) formulation of salmeterol with an investigational hydrofluoroalkane (HFA) formulation. Methods: This was a randomized, double-blind, placebo-controlled, 3-way crossover study in patients with mild to moderate asthma who had a forced expiratory volume in 1 second (FEV 1) of

Original language	English
Pages (from-to)	1004-1012
Number of pages	8
Journal	Clinical Therapeutics
Volume	27
Issue number	7
DOIs	https://doi.org/10.1016/j.clinthera.2005.07.006
Publication status	Published - Jul 2005

Keywords

Asthma
Chlorofluorocarbon
Fine-particle mass
Hydrofluoroalkane
Methacholine challenge
Salmeterol

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10.1016/j.clinthera.2005.07.006

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Allen, D., McDonnell, B., Wheeler, N., Sharma, R. K., Sykes, A., & Woodcock, A. (2005). The effect of reducing the fine-particle mass of salmeterol from metered-dose inhalers on bronchodilatation and bronchoprotection against methacholine challenge: A randomized, placebo-controlled, double-blind, crossover study. Clinical Therapeutics, 27(7), 1004-1012. https://doi.org/10.1016/j.clinthera.2005.07.006

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abstract = "Objective: This study examined the clinical relevance of fine-particle mass (FPM) delivered from metered dose inhalers (MDIs) to bronchodilatation and bronchoprotection against methacholine challenge by comparing a marketed chlorofluorocarbon (CFC) formulation of salmeterol with an investigational hydrofluoroalkane (HFA) formulation. Methods: This was a randomized, double-blind, placebo-controlled, 3-way crossover study in patients with mild to moderate asthma who had a forced expiratory volume in 1 second (FEV 1) of",

keywords = "Asthma, Chlorofluorocarbon, Fine-particle mass, Hydrofluoroalkane, Methacholine challenge, Salmeterol",

author = "David Allen and Barbara McDonnell and Neil Wheeler and Sharma, {Raj K.} and Andrew Sykes and Ashley Woodcock",

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Allen, D, McDonnell, B, Wheeler, N, Sharma, RK, Sykes, A & Woodcock, A 2005, 'The effect of reducing the fine-particle mass of salmeterol from metered-dose inhalers on bronchodilatation and bronchoprotection against methacholine challenge: A randomized, placebo-controlled, double-blind, crossover study', Clinical Therapeutics, vol. 27, no. 7, pp. 1004-1012. https://doi.org/10.1016/j.clinthera.2005.07.006

The effect of reducing the fine-particle mass of salmeterol from metered-dose inhalers on bronchodilatation and bronchoprotection against methacholine challenge: A randomized, placebo-controlled, double-blind, crossover study. / Allen, David; McDonnell, Barbara; Wheeler, Neil et al.

In: Clinical Therapeutics, Vol. 27, No. 7, 07.2005, p. 1004-1012.

Research output: Contribution to journal › Article › peer-review

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KW - Chlorofluorocarbon

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KW - Hydrofluoroalkane

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Allen D, McDonnell B, Wheeler N, Sharma RK, Sykes A, Woodcock A. The effect of reducing the fine-particle mass of salmeterol from metered-dose inhalers on bronchodilatation and bronchoprotection against methacholine challenge: A randomized, placebo-controlled, double-blind, crossover study. Clinical Therapeutics. 2005 Jul;27(7):1004-1012. doi: 10.1016/j.clinthera.2005.07.006