The effect of the intrauterine contraceptive device on endometrial secretory function: A possible mode of action

M. W. Seif; J. D. Aplin; H. Awad; D. Wells

The effect of the intrauterine contraceptive device on endometrial secretory function: A possible mode of action

M. W. Seif, J. D. Aplin, H. Awad, D. Wells

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of the intrauterine contraceptive device (IUD) on the composition of endometrial secretion has been studied using the monoclonal antibody D9B1. The antibody binds to a polypeptide-associated oligosaccharide epitope that is secreted by endometrial epithelium in the secretory phase with a maximum around the time of implantation. In endometria affected by the IUD in situ, a significant reduction in epitope expression has been observed using immunohistochemistry. This defect can occur against a background of normal secretory differentiation and in the expectation of normal ovarian stimulus. The data provide new insight into the contraceptive mechanisms of action of the IUD. © 1989.

Original language	English
Pages (from-to)	81-89
Number of pages	8
Journal	Contraception
Volume	40
Issue number	1
Publication status	Published - Jul 1989

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abstract = "The effect of the intrauterine contraceptive device (IUD) on the composition of endometrial secretion has been studied using the monoclonal antibody D9B1. The antibody binds to a polypeptide-associated oligosaccharide epitope that is secreted by endometrial epithelium in the secretory phase with a maximum around the time of implantation. In endometria affected by the IUD in situ, a significant reduction in epitope expression has been observed using immunohistochemistry. This defect can occur against a background of normal secretory differentiation and in the expectation of normal ovarian stimulus. The data provide new insight into the contraceptive mechanisms of action of the IUD. {\textcopyright} 1989.",

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AU - Awad, H.

AU - Wells, D.

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N2 - The effect of the intrauterine contraceptive device (IUD) on the composition of endometrial secretion has been studied using the monoclonal antibody D9B1. The antibody binds to a polypeptide-associated oligosaccharide epitope that is secreted by endometrial epithelium in the secretory phase with a maximum around the time of implantation. In endometria affected by the IUD in situ, a significant reduction in epitope expression has been observed using immunohistochemistry. This defect can occur against a background of normal secretory differentiation and in the expectation of normal ovarian stimulus. The data provide new insight into the contraceptive mechanisms of action of the IUD. © 1989.

AB - The effect of the intrauterine contraceptive device (IUD) on the composition of endometrial secretion has been studied using the monoclonal antibody D9B1. The antibody binds to a polypeptide-associated oligosaccharide epitope that is secreted by endometrial epithelium in the secretory phase with a maximum around the time of implantation. In endometria affected by the IUD in situ, a significant reduction in epitope expression has been observed using immunohistochemistry. This defect can occur against a background of normal secretory differentiation and in the expectation of normal ovarian stimulus. The data provide new insight into the contraceptive mechanisms of action of the IUD. © 1989.

M3 - Article

C2 - 0002476276

SN - 0010-7824

VL - 40

SP - 81

EP - 89

JO - Contraception

JF - Contraception

IS - 1

ER -

The effect of the intrauterine contraceptive device on endometrial secretory function: A possible mode of action

Abstract

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