The effects of cholecystokinin on dopaminergic mechanisms in rat striatum

R D Mashal, F Owen, J F Deakin, M Poulter

Research output: Contribution to journalArticlepeer-review


Intraventricular administration of cholecystokinin-octapeptide in unanesthetized rats results in a significant reduction in the number of [3H]spiperone binding sites. Striatal levels of the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly reduced, whereas there was no significant reduction in the levels of the serotonin metabolite 5-hydroxyindoleacetic acid.

Original languageEnglish
Pages (from-to)375-6
Number of pages2
JournalBrain research
Issue number2
Publication statusPublished - 31 Oct 1983


  • Animals
  • Corpus Striatum
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, Dopamine
  • Receptors, Dopamine D2
  • Sincalide
  • Spiperone
  • Journal Article


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