The effects of cholecystokinin on dopaminergic mechanisms in rat striatum

R D Mashal; F Owen; J F Deakin; M Poulter

doi:10.1016/0006-8993(83)90949-6

The effects of cholecystokinin on dopaminergic mechanisms in rat striatum

R D Mashal, F Owen, J F Deakin, M Poulter

Division of Neuroscience

Research output: Contribution to journal › Article › peer-review

Abstract

Intraventricular administration of cholecystokinin-octapeptide in unanesthetized rats results in a significant reduction in the number of [3H]spiperone binding sites. Striatal levels of the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly reduced, whereas there was no significant reduction in the levels of the serotonin metabolite 5-hydroxyindoleacetic acid.

Original language	English
Pages (from-to)	375-6
Number of pages	2
Journal	Brain research
Volume	277
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(83)90949-6
Publication status	Published - 31 Oct 1983

Keywords

Animals
Corpus Striatum
Male
Rats
Rats, Inbred Strains
Receptors, Dopamine
Receptors, Dopamine D2
Sincalide
Spiperone
Journal Article

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10.1016/0006-8993(83)90949-6

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title = "The effects of cholecystokinin on dopaminergic mechanisms in rat striatum",

abstract = "Intraventricular administration of cholecystokinin-octapeptide in unanesthetized rats results in a significant reduction in the number of [3H]spiperone binding sites. Striatal levels of the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly reduced, whereas there was no significant reduction in the levels of the serotonin metabolite 5-hydroxyindoleacetic acid.",

keywords = "Animals, Corpus Striatum, Male, Rats, Rats, Inbred Strains, Receptors, Dopamine, Receptors, Dopamine D2, Sincalide, Spiperone, Journal Article",

author = "Mashal, {R D} and F Owen and Deakin, {J F} and M Poulter",

year = "1983",

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T1 - The effects of cholecystokinin on dopaminergic mechanisms in rat striatum

AU - Mashal, R D

AU - Owen, F

AU - Deakin, J F

AU - Poulter, M

PY - 1983/10/31

Y1 - 1983/10/31

N2 - Intraventricular administration of cholecystokinin-octapeptide in unanesthetized rats results in a significant reduction in the number of [3H]spiperone binding sites. Striatal levels of the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly reduced, whereas there was no significant reduction in the levels of the serotonin metabolite 5-hydroxyindoleacetic acid.

AB - Intraventricular administration of cholecystokinin-octapeptide in unanesthetized rats results in a significant reduction in the number of [3H]spiperone binding sites. Striatal levels of the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly reduced, whereas there was no significant reduction in the levels of the serotonin metabolite 5-hydroxyindoleacetic acid.

KW - Animals

KW - Corpus Striatum

KW - Male

KW - Rats

KW - Rats, Inbred Strains

KW - Receptors, Dopamine

KW - Receptors, Dopamine D2

KW - Sincalide

KW - Spiperone

KW - Journal Article

U2 - 10.1016/0006-8993(83)90949-6

DO - 10.1016/0006-8993(83)90949-6

M3 - Article

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SN - 0006-8993

VL - 277

SP - 375

EP - 376

JO - Brain research

JF - Brain research

IS - 2

ER -

The effects of cholecystokinin on dopaminergic mechanisms in rat striatum

Abstract

Keywords

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