The effects of halothane anaesthesia on antibody dependent cellular cytotoxicity in rats

B. M. Vose, I. Kimber

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Lymphocytes from rats killed while anaesthetized with 1.5 per cent halothane showed a significantly reduced capacity to induce lysis of antibody-coated target cells compared with those from untreated rats. This effect was short-lived however, being no longer apparent in lymphoid cells taken from rats 2 h after their recovery from such anesthesia. Surgical procedures were not effective in extending the duration of reduced ADCC activity. The implication of these findings is that the post-operative depression of this in vitro assay of immunocompetence results from the influence of the anaesthetic agent per se or its metabolites with surgical trauma having little role.
    Original languageEnglish
    Pages (from-to)609-615
    Number of pages6
    JournalImmunology
    Volume32
    Issue number5
    Publication statusPublished - 1977

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