The effects of stretch on vascular smooth muscle cell phenotype in vitro

Anastassi T. Halka; Neill J. Turner; Andrew Carter; Jonathan Ghosh; Michael O. Murphy; John P. Kirton; Cay M. Kielty; Michael G. Walker

doi:10.1016/j.carpath.2007.03.001

The effects of stretch on vascular smooth muscle cell phenotype in vitro

Anastassi T. Halka, Neill J. Turner, Andrew Carter, Jonathan Ghosh, Michael O. Murphy, John P. Kirton, Cay M. Kielty, Michael G. Walker

Research output: Contribution to journal › Article › peer-review

Abstract

Vascular smooth muscle cells (VSMC) situated in the tunica media of veins and arteries are central to maintaining conduit integrity in the face of mechanical forces inherent within the cardiovascular system. The predominant mechanical force influencing VSMC structural organisation and signalling is cyclic stretch. VSMC phenotype is manipulated by externally applied stretch which regulates the activity of their contractile apparatus. Stretch modulates cell shape, cytoplasmic organisation, and intracellular processes leading to migration, proliferation, or contraction. Drug therapy directed at the components of the signalling pathways influenced by stretch may ultimately prevent cardiovascular pathology such as myointimal hyperplasia. © 2008 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	98-102
Number of pages	4
Journal	Cardiovascular Pathology
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/j.carpath.2007.03.001
Publication status	Published - Mar 2008

Keywords

FAK
Phenotype
RhoA
Signalling
Stretch
Vascular smooth muscle cells

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10.1016/j.carpath.2007.03.001

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title = "The effects of stretch on vascular smooth muscle cell phenotype in vitro",

abstract = "Vascular smooth muscle cells (VSMC) situated in the tunica media of veins and arteries are central to maintaining conduit integrity in the face of mechanical forces inherent within the cardiovascular system. The predominant mechanical force influencing VSMC structural organisation and signalling is cyclic stretch. VSMC phenotype is manipulated by externally applied stretch which regulates the activity of their contractile apparatus. Stretch modulates cell shape, cytoplasmic organisation, and intracellular processes leading to migration, proliferation, or contraction. Drug therapy directed at the components of the signalling pathways influenced by stretch may ultimately prevent cardiovascular pathology such as myointimal hyperplasia. {\textcopyright} 2008 Elsevier Inc. All rights reserved.",

keywords = "FAK, Phenotype, RhoA, Signalling, Stretch, Vascular smooth muscle cells",

author = "Halka, {Anastassi T.} and Turner, {Neill J.} and Andrew Carter and Jonathan Ghosh and Murphy, {Michael O.} and Kirton, {John P.} and Kielty, {Cay M.} and Walker, {Michael G.}",

year = "2008",

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doi = "10.1016/j.carpath.2007.03.001",

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volume = "17",

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T1 - The effects of stretch on vascular smooth muscle cell phenotype in vitro

AU - Halka, Anastassi T.

AU - Turner, Neill J.

AU - Carter, Andrew

AU - Ghosh, Jonathan

AU - Murphy, Michael O.

AU - Kirton, John P.

AU - Kielty, Cay M.

AU - Walker, Michael G.

PY - 2008/3

Y1 - 2008/3

N2 - Vascular smooth muscle cells (VSMC) situated in the tunica media of veins and arteries are central to maintaining conduit integrity in the face of mechanical forces inherent within the cardiovascular system. The predominant mechanical force influencing VSMC structural organisation and signalling is cyclic stretch. VSMC phenotype is manipulated by externally applied stretch which regulates the activity of their contractile apparatus. Stretch modulates cell shape, cytoplasmic organisation, and intracellular processes leading to migration, proliferation, or contraction. Drug therapy directed at the components of the signalling pathways influenced by stretch may ultimately prevent cardiovascular pathology such as myointimal hyperplasia. © 2008 Elsevier Inc. All rights reserved.

AB - Vascular smooth muscle cells (VSMC) situated in the tunica media of veins and arteries are central to maintaining conduit integrity in the face of mechanical forces inherent within the cardiovascular system. The predominant mechanical force influencing VSMC structural organisation and signalling is cyclic stretch. VSMC phenotype is manipulated by externally applied stretch which regulates the activity of their contractile apparatus. Stretch modulates cell shape, cytoplasmic organisation, and intracellular processes leading to migration, proliferation, or contraction. Drug therapy directed at the components of the signalling pathways influenced by stretch may ultimately prevent cardiovascular pathology such as myointimal hyperplasia. © 2008 Elsevier Inc. All rights reserved.

KW - FAK

KW - Phenotype

KW - RhoA

KW - Signalling

KW - Stretch

KW - Vascular smooth muscle cells

U2 - 10.1016/j.carpath.2007.03.001

DO - 10.1016/j.carpath.2007.03.001

M3 - Article

SN - 1054-8807

VL - 17

SP - 98

EP - 102

JO - Cardiovascular Pathology

JF - Cardiovascular Pathology

IS - 2

ER -

The effects of stretch on vascular smooth muscle cell phenotype in vitro

Abstract

Keywords

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