The emergence of plasma memebrane calcium pump as a novel therapeutic target for heart disease

Ludwig Neyses; Delvac Oceandy; Mamta H. Buch; Elizabeth J. Cartwright; Ludwig Neyse

doi:10.2174/138955706776876177

The emergence of plasma memebrane calcium pump as a novel therapeutic target for heart disease

Ludwig Neyses, Delvac Oceandy, Mamta H. Buch, Elizabeth J. Cartwright, Ludwig Neyse

Research output: Contribution to journal › Article › peer-review

Abstract

The plasma membrane calcium/calmodulin dependent ATPase (PMCA) is a calcium-extruding enzymatic pump important in the control of intracellular calcium concentration. PMCA is the only system for calcium extrusion in the majority of cells. In excitable cells such as cardiomyocytes however, PMCA has been shown to play only a minor role in calcium homeostasis. In these cells the main mechanism of calcium extrusion is the sodium calcium exchanger. However, increasing evidence points to an important role for PMCA in signal transduction; in particular in the nitric oxide signalling pathway. In this review we will discuss recent advances that support a key role for PMCA in signal transduction and the potential for therapeutic targeting of this molecule in the treatment of cardiac diseases. © 2006 Bentham Science Publishers Ltd.

Original language	English
Pages (from-to)	583-588
Number of pages	5
Journal	Mini reviews in medicinal chemistry
Volume	6
Issue number	5
DOIs	https://doi.org/10.2174/138955706776876177
Publication status	Published - May 2006

Keywords

Cardiovascular disease
Neuronal nitric oxide synthase
Plasma membrane calcium pump
Signal transduction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/138955706776876177

http://www.ingentaconnect.com/content/ben/mrmc/2006/00000006/00000005/art00013

Cite this

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title = "The emergence of plasma memebrane calcium pump as a novel therapeutic target for heart disease",

abstract = "The plasma membrane calcium/calmodulin dependent ATPase (PMCA) is a calcium-extruding enzymatic pump important in the control of intracellular calcium concentration. PMCA is the only system for calcium extrusion in the majority of cells. In excitable cells such as cardiomyocytes however, PMCA has been shown to play only a minor role in calcium homeostasis. In these cells the main mechanism of calcium extrusion is the sodium calcium exchanger. However, increasing evidence points to an important role for PMCA in signal transduction; in particular in the nitric oxide signalling pathway. In this review we will discuss recent advances that support a key role for PMCA in signal transduction and the potential for therapeutic targeting of this molecule in the treatment of cardiac diseases. {\textcopyright} 2006 Bentham Science Publishers Ltd.",

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author = "Ludwig Neyses and Delvac Oceandy and Buch, {Mamta H.} and Cartwright, {Elizabeth J.} and Ludwig Neyse",

year = "2006",

month = may,

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language = "English",

volume = "6",

pages = "583--588",

journal = "Mini reviews in medicinal chemistry",

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T1 - The emergence of plasma memebrane calcium pump as a novel therapeutic target for heart disease

AU - Neyses, Ludwig

AU - Oceandy, Delvac

AU - Buch, Mamta H.

AU - Cartwright, Elizabeth J.

AU - Neyse, Ludwig

PY - 2006/5

Y1 - 2006/5

N2 - The plasma membrane calcium/calmodulin dependent ATPase (PMCA) is a calcium-extruding enzymatic pump important in the control of intracellular calcium concentration. PMCA is the only system for calcium extrusion in the majority of cells. In excitable cells such as cardiomyocytes however, PMCA has been shown to play only a minor role in calcium homeostasis. In these cells the main mechanism of calcium extrusion is the sodium calcium exchanger. However, increasing evidence points to an important role for PMCA in signal transduction; in particular in the nitric oxide signalling pathway. In this review we will discuss recent advances that support a key role for PMCA in signal transduction and the potential for therapeutic targeting of this molecule in the treatment of cardiac diseases. © 2006 Bentham Science Publishers Ltd.

AB - The plasma membrane calcium/calmodulin dependent ATPase (PMCA) is a calcium-extruding enzymatic pump important in the control of intracellular calcium concentration. PMCA is the only system for calcium extrusion in the majority of cells. In excitable cells such as cardiomyocytes however, PMCA has been shown to play only a minor role in calcium homeostasis. In these cells the main mechanism of calcium extrusion is the sodium calcium exchanger. However, increasing evidence points to an important role for PMCA in signal transduction; in particular in the nitric oxide signalling pathway. In this review we will discuss recent advances that support a key role for PMCA in signal transduction and the potential for therapeutic targeting of this molecule in the treatment of cardiac diseases. © 2006 Bentham Science Publishers Ltd.

KW - Cardiovascular disease

KW - Neuronal nitric oxide synthase

KW - Plasma membrane calcium pump

KW - Signal transduction

U2 - 10.2174/138955706776876177

DO - 10.2174/138955706776876177

M3 - Article

VL - 6

SP - 583

EP - 588

JO - Mini reviews in medicinal chemistry

JF - Mini reviews in medicinal chemistry

IS - 5

ER -

The emergence of plasma memebrane calcium pump as a novel therapeutic target for heart disease

Abstract

Keywords

UN SDGs

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