The expanding family of regulatory B cells

Claudia Mauri, Madhvi Menon

Research output: Contribution to journalReview articlepeer-review


Over the last decade it has become evident that in addition to producing antibody, B cells activate the immune system by producing cytokines and via antigen presentation. In addition, B cells also exhibit immunosuppressive functions via diverse regulatory mechanisms. This subset of B cells, known as regulatory B cells (Bregs), contributes to the maintenance of tolerance, primarily via the production of IL-10. Studies in experimental animal models, as well as in patients with autoimmune diseases, have identified multiple Breg subsets exhibiting diverse mechanisms of immune suppression. In this review, we describe the different Breg subsets identified in mice and humans, and their diverse mechanisms of suppression in different disease settings.

Original languageEnglish
Pages (from-to)479-86
Number of pages8
JournalInternational immunology
Issue number10
Publication statusPublished - 12 Jun 2015


  • Animals
  • Antigen Presentation
  • Antigens, CD/genetics
  • Autoimmune Diseases/genetics
  • B-Lymphocytes, Regulatory/immunology
  • Cell Communication
  • Cell Lineage/immunology
  • Disease Models, Animal
  • Gene Expression Regulation/immunology
  • Humans
  • Immune Tolerance
  • Immunity, Humoral
  • Interleukin-10/genetics
  • Mice
  • Signal Transduction
  • T-Lymphocytes, Regulatory/immunology


Dive into the research topics of 'The expanding family of regulatory B cells'. Together they form a unique fingerprint.

Cite this