The expanding family of regulatory B cells

Claudia Mauri, Madhvi Menon

Research output: Contribution to journalReview articlepeer-review

Abstract

Over the last decade it has become evident that in addition to producing antibody, B cells activate the immune system by producing cytokines and via antigen presentation. In addition, B cells also exhibit immunosuppressive functions via diverse regulatory mechanisms. This subset of B cells, known as regulatory B cells (Bregs), contributes to the maintenance of tolerance, primarily via the production of IL-10. Studies in experimental animal models, as well as in patients with autoimmune diseases, have identified multiple Breg subsets exhibiting diverse mechanisms of immune suppression. In this review, we describe the different Breg subsets identified in mice and humans, and their diverse mechanisms of suppression in different disease settings.

Original languageEnglish
Pages (from-to)479-86
Number of pages8
JournalInternational immunology
Volume27
Issue number10
DOIs
Publication statusPublished - 12 Jun 2015

Keywords

  • Animals
  • Antigen Presentation
  • Antigens, CD/genetics
  • Autoimmune Diseases/genetics
  • B-Lymphocytes, Regulatory/immunology
  • Cell Communication
  • Cell Lineage/immunology
  • Disease Models, Animal
  • Gene Expression Regulation/immunology
  • Humans
  • Immune Tolerance
  • Immunity, Humoral
  • Interleukin-10/genetics
  • Mice
  • Signal Transduction
  • T-Lymphocytes, Regulatory/immunology

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