TY - JOUR
T1 - The Facile Synthesis of Exogenous Lewis-Base-Free Amidoalanes: A Structural Comparison
AU - Hemsworth, Jake
AU - Vinogradov, Andrej
AU - Lewis, William
AU - Woodward, Simon
AU - Willcox, Darren
PY - 2025/2/20
Y1 - 2025/2/20
N2 - A simple one-pot reaction of LiAlH4, AlCl3, and a secondary amine HNR2 [R = Et, iPr, iBu, cyclo-C6H11, (CH2)4, and (CH2)5] in hydrocarbon solvents results in the formation of exogenous Lewis-base-free amidoalanes [H2Al(NR2)]n (n = 2 or 3) as crystalline solids (35–85% yield). In the solid state (seven X-ray structures), all the amidoalanes exist as dimers, with the exception of the pyrrolidine-derived alane which exists as a trimer. As solids, these amidoalanes exhibit significant kinetic stability towards oxygen/moisture allowing the brief (ca. 5 min.) handling of [H2Al(NiPr2)]2 in air.
AB - A simple one-pot reaction of LiAlH4, AlCl3, and a secondary amine HNR2 [R = Et, iPr, iBu, cyclo-C6H11, (CH2)4, and (CH2)5] in hydrocarbon solvents results in the formation of exogenous Lewis-base-free amidoalanes [H2Al(NR2)]n (n = 2 or 3) as crystalline solids (35–85% yield). In the solid state (seven X-ray structures), all the amidoalanes exist as dimers, with the exception of the pyrrolidine-derived alane which exists as a trimer. As solids, these amidoalanes exhibit significant kinetic stability towards oxygen/moisture allowing the brief (ca. 5 min.) handling of [H2Al(NiPr2)]2 in air.
U2 - 10.3390/molecules30050986
DO - 10.3390/molecules30050986
M3 - Article
SN - 1420-3049
VL - 30
JO - Molecules
JF - Molecules
IS - 5
M1 - 986
ER -