The frequency and outcome of lupus nephritis: results from an international inception cohort study.

John G Hanly; Aidan G O'Keeffe; Li Su; Murray B Urowitz; Juanita Romero-Diaz; Caroline Gordon; Sang-Cheol Bae; Sasha Bernatsky; Ann E Clarke; Daniel J Wallace; Joan T Merrill; David A Isenberg; Anisur Rahman; Ellen M Ginzler; Paul Fortin; Dafna D Gladman; Jorge Sanchez-Guerrero; Michelle Petri; Ian N Bruce; Mary Anne Dooley; Rosalind Ramsey-Goldman; Cynthia Aranow; Graciela S Alarcón; Barri J Fessler; Kristjan Steinsson; Ola Nived; Gunnar K Sturfelt; Susan Manzi; Munther A Khamashta; Ronald F van Vollenhoven; Asad A Zoma; Manuel Ramos-Casals; Guillermo Ruiz-Irastorza; S Sam Lim; Thomas Stoll; Murat Inanc; Kenneth C Kalunian; Diane L Kamen; Peter Maddison; Christine A Peschken; Soren Jacobsen; Anca Askanase; Chris Theriault; Kara Thompson; Vernon Farewell

doi:10.1093/rheumatology/kev311

The frequency and outcome of lupus nephritis: results from an international inception cohort study.

John G Hanly, Aidan G O'Keeffe, Li Su, Murray B Urowitz, Juanita Romero-Diaz, Caroline Gordon, Sang-Cheol Bae, Sasha Bernatsky, Ann E Clarke, Daniel J Wallace, Joan T Merrill, David A Isenberg, Anisur Rahman, Ellen M Ginzler, Paul Fortin, Dafna D Gladman, Jorge Sanchez-Guerrero, Michelle Petri, Ian N Bruce, Mary Anne DooleyRosalind Ramsey-Goldman, Cynthia Aranow, Graciela S Alarcón, Barri J Fessler, Kristjan Steinsson, Ola Nived, Gunnar K Sturfelt, Susan Manzi, Munther A Khamashta, Ronald F van Vollenhoven, Asad A Zoma, Manuel Ramos-Casals, Guillermo Ruiz-Irastorza, S Sam Lim, Thomas Stoll, Murat Inanc, Kenneth C Kalunian, Diane L Kamen, Peter Maddison, Christine A Peschken, Soren Jacobsen, Anca Askanase, Chris Theriault, Kara Thompson, Vernon Farewell

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort. METHODS: Patients in the Systemic Lupus International Collaborating Clinics inception cohort (≤15 months of SLE diagnosis) were assessed annually for estimated glomerular filtration rate (eGFR), proteinuria and end-stage renal disease (ESRD). Health-related quality of life was measured by the Short Form (36 questions) health survey questionnaire (SF-36) subscales, mental and physical component summary scores. RESULTS: There were 1827 patients, 89% females, mean (s.d.) age 35.1 (13.3) years. The mean (s.d.) SLE duration at enrolment was 0.5 (0.3) years and follow-up 4.6 (3.4) years. LN occurred in 700 (38.3%) patients: 566/700 (80.9%) at enrolment and 134/700 (19.1%) during follow-up. Patients with nephritis were younger, more frequently men and of African, Asian and Hispanic race/ethnicity. The estimated overall 10-year incidence of ESRD was 4.3% (95% CI: 2.8%, 5.8%), and with nephritis was 10.1% (95% CI: 6.6%, 13.6%). Patients with nephritis had a higher risk of death (HR = 2.98, 95% CI: 1.48, 5.99; P = 0.002) and those with eGFR

Original language	English
Pages (from-to)	252-262
Number of pages	10
Journal	Rheumatology (Oxford, England)
Volume	55
Issue number	2
DOIs	https://doi.org/10.1093/rheumatology/kev311
Publication status	Published - 2016

Keywords

inception cohort
lupus
nephritis
outcomes research
systemic lupus erythematosus

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10.1093/rheumatology/kev311

Arthritis Research UK Centre of Excellence in Epidemiology.
Symmons, D. (PI), Bruce, I. (CoI), Dixon, W. (CoI), Felson, D. (CoI), Hyrich, K. (CoI), Lunt, M. (CoI), Mcbeth, J. (CoI), O'Neill, T. (CoI) & Verstappen, S. (CoI)
1/08/13 → 31/07/18
Project: Research

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Hanly, J. G., O'Keeffe, A. G., Su, L., Urowitz, M. B., Romero-Diaz, J., Gordon, C., Bae, S.-C., Bernatsky, S., Clarke, A. E., Wallace, D. J., Merrill, J. T., Isenberg, D. A., Rahman, A., Ginzler, E. M., Fortin, P., Gladman, D. D., Sanchez-Guerrero, J., Petri, M., Bruce, I. N., ... Farewell, V. (2016). The frequency and outcome of lupus nephritis: results from an international inception cohort study. Rheumatology (Oxford, England), 55(2), 252-262. https://doi.org/10.1093/rheumatology/kev311

@article{87dbd4cdb7a74e10aca8055ca693c081,

title = "The frequency and outcome of lupus nephritis: results from an international inception cohort study.",

abstract = "OBJECTIVE: To determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort. METHODS: Patients in the Systemic Lupus International Collaborating Clinics inception cohort (≤15 months of SLE diagnosis) were assessed annually for estimated glomerular filtration rate (eGFR), proteinuria and end-stage renal disease (ESRD). Health-related quality of life was measured by the Short Form (36 questions) health survey questionnaire (SF-36) subscales, mental and physical component summary scores. RESULTS: There were 1827 patients, 89% females, mean (s.d.) age 35.1 (13.3) years. The mean (s.d.) SLE duration at enrolment was 0.5 (0.3) years and follow-up 4.6 (3.4) years. LN occurred in 700 (38.3%) patients: 566/700 (80.9%) at enrolment and 134/700 (19.1%) during follow-up. Patients with nephritis were younger, more frequently men and of African, Asian and Hispanic race/ethnicity. The estimated overall 10-year incidence of ESRD was 4.3% (95% CI: 2.8%, 5.8%), and with nephritis was 10.1% (95% CI: 6.6%, 13.6%). Patients with nephritis had a higher risk of death (HR = 2.98, 95% CI: 1.48, 5.99; P = 0.002) and those with eGFR",

keywords = "inception cohort, lupus, nephritis, outcomes research, systemic lupus erythematosus",

author = "Hanly, {John G} and O'Keeffe, {Aidan G} and Li Su and Urowitz, {Murray B} and Juanita Romero-Diaz and Caroline Gordon and Sang-Cheol Bae and Sasha Bernatsky and Clarke, {Ann E} and Wallace, {Daniel J} and Merrill, {Joan T} and Isenberg, {David A} and Anisur Rahman and Ginzler, {Ellen M} and Paul Fortin and Gladman, {Dafna D} and Jorge Sanchez-Guerrero and Michelle Petri and Bruce, {Ian N} and Dooley, {Mary Anne} and Rosalind Ramsey-Goldman and Cynthia Aranow and Alarc{\'o}n, {Graciela S} and Fessler, {Barri J} and Kristjan Steinsson and Ola Nived and Sturfelt, {Gunnar K} and Susan Manzi and Khamashta, {Munther A} and {van Vollenhoven}, {Ronald F} and Zoma, {Asad A} and Manuel Ramos-Casals and Guillermo Ruiz-Irastorza and Lim, {S Sam} and Thomas Stoll and Murat Inanc and Kalunian, {Kenneth C} and Kamen, {Diane L} and Peter Maddison and Peschken, {Christine A} and Soren Jacobsen and Anca Askanase and Chris Theriault and Kara Thompson and Vernon Farewell",

year = "2016",

doi = "10.1093/rheumatology/kev311",

language = "English",

volume = "55",

pages = "252--262",

journal = "Rheumatology (Oxford, England)",

issn = "1462-0332",

publisher = "Oxford University Press",

number = "2",

}

Hanly, JG, O'Keeffe, AG, Su, L, Urowitz, MB, Romero-Diaz, J, Gordon, C, Bae, S-C, Bernatsky, S, Clarke, AE, Wallace, DJ, Merrill, JT, Isenberg, DA, Rahman, A, Ginzler, EM, Fortin, P, Gladman, DD, Sanchez-Guerrero, J, Petri, M, Bruce, IN, Dooley, MA, Ramsey-Goldman, R, Aranow, C, Alarcón, GS, Fessler, BJ, Steinsson, K, Nived, O, Sturfelt, GK, Manzi, S, Khamashta, MA, van Vollenhoven, RF, Zoma, AA, Ramos-Casals, M, Ruiz-Irastorza, G, Lim, SS, Stoll, T, Inanc, M, Kalunian, KC, Kamen, DL, Maddison, P, Peschken, CA, Jacobsen, S, Askanase, A, Theriault, C, Thompson, K & Farewell, V 2016, 'The frequency and outcome of lupus nephritis: results from an international inception cohort study.', Rheumatology (Oxford, England), vol. 55, no. 2, pp. 252-262. https://doi.org/10.1093/rheumatology/kev311

TY - JOUR

T1 - The frequency and outcome of lupus nephritis: results from an international inception cohort study.

AU - Hanly, John G

AU - O'Keeffe, Aidan G

AU - Su, Li

AU - Urowitz, Murray B

AU - Romero-Diaz, Juanita

AU - Gordon, Caroline

AU - Bae, Sang-Cheol

AU - Bernatsky, Sasha

AU - Clarke, Ann E

AU - Wallace, Daniel J

AU - Merrill, Joan T

AU - Isenberg, David A

AU - Rahman, Anisur

AU - Ginzler, Ellen M

AU - Fortin, Paul

AU - Gladman, Dafna D

AU - Sanchez-Guerrero, Jorge

AU - Petri, Michelle

AU - Bruce, Ian N

AU - Dooley, Mary Anne

AU - Ramsey-Goldman, Rosalind

AU - Aranow, Cynthia

AU - Alarcón, Graciela S

AU - Fessler, Barri J

AU - Steinsson, Kristjan

AU - Nived, Ola

AU - Sturfelt, Gunnar K

AU - Manzi, Susan

AU - Khamashta, Munther A

AU - van Vollenhoven, Ronald F

AU - Zoma, Asad A

AU - Ramos-Casals, Manuel

AU - Ruiz-Irastorza, Guillermo

AU - Lim, S Sam

AU - Stoll, Thomas

AU - Inanc, Murat

AU - Kalunian, Kenneth C

AU - Kamen, Diane L

AU - Maddison, Peter

AU - Peschken, Christine A

AU - Jacobsen, Soren

AU - Askanase, Anca

AU - Theriault, Chris

AU - Thompson, Kara

AU - Farewell, Vernon

PY - 2016

Y1 - 2016

N2 - OBJECTIVE: To determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort. METHODS: Patients in the Systemic Lupus International Collaborating Clinics inception cohort (≤15 months of SLE diagnosis) were assessed annually for estimated glomerular filtration rate (eGFR), proteinuria and end-stage renal disease (ESRD). Health-related quality of life was measured by the Short Form (36 questions) health survey questionnaire (SF-36) subscales, mental and physical component summary scores. RESULTS: There were 1827 patients, 89% females, mean (s.d.) age 35.1 (13.3) years. The mean (s.d.) SLE duration at enrolment was 0.5 (0.3) years and follow-up 4.6 (3.4) years. LN occurred in 700 (38.3%) patients: 566/700 (80.9%) at enrolment and 134/700 (19.1%) during follow-up. Patients with nephritis were younger, more frequently men and of African, Asian and Hispanic race/ethnicity. The estimated overall 10-year incidence of ESRD was 4.3% (95% CI: 2.8%, 5.8%), and with nephritis was 10.1% (95% CI: 6.6%, 13.6%). Patients with nephritis had a higher risk of death (HR = 2.98, 95% CI: 1.48, 5.99; P = 0.002) and those with eGFR

AB - OBJECTIVE: To determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort. METHODS: Patients in the Systemic Lupus International Collaborating Clinics inception cohort (≤15 months of SLE diagnosis) were assessed annually for estimated glomerular filtration rate (eGFR), proteinuria and end-stage renal disease (ESRD). Health-related quality of life was measured by the Short Form (36 questions) health survey questionnaire (SF-36) subscales, mental and physical component summary scores. RESULTS: There were 1827 patients, 89% females, mean (s.d.) age 35.1 (13.3) years. The mean (s.d.) SLE duration at enrolment was 0.5 (0.3) years and follow-up 4.6 (3.4) years. LN occurred in 700 (38.3%) patients: 566/700 (80.9%) at enrolment and 134/700 (19.1%) during follow-up. Patients with nephritis were younger, more frequently men and of African, Asian and Hispanic race/ethnicity. The estimated overall 10-year incidence of ESRD was 4.3% (95% CI: 2.8%, 5.8%), and with nephritis was 10.1% (95% CI: 6.6%, 13.6%). Patients with nephritis had a higher risk of death (HR = 2.98, 95% CI: 1.48, 5.99; P = 0.002) and those with eGFR

KW - inception cohort

KW - lupus

KW - nephritis

KW - outcomes research

KW - systemic lupus erythematosus

U2 - 10.1093/rheumatology/kev311

DO - 10.1093/rheumatology/kev311

M3 - Article

C2 - 26342222

SN - 1462-0332

VL - 55

SP - 252

EP - 262

JO - Rheumatology (Oxford, England)

JF - Rheumatology (Oxford, England)

IS - 2

ER -

The frequency and outcome of lupus nephritis: results from an international inception cohort study.

Abstract

Keywords

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Arthritis Research UK Centre of Excellence in Epidemiology.

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