The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing

Rebecca Hogg; Joanne C. McGrail; Raymond T. O'Keefe

doi:10.1042/BST0381110

The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing

Rebecca Hogg, Joanne C. McGrail, Raymond T. O'Keefe

Research output: Contribution to journal › Article › peer-review

Abstract

The NineTeen Complex (NTC) of proteins associates with the spliceosome during pre-mRNA splicing and is essential for both steps of intron removal. The NTC and other NTC-associated proteins are recruited to the spliceosome where they participate in regulating the formation and progression of essential spliceosome conformations required for the two steps of splicing. It is now clear that the NTC is an integral component of active spliceosomes from yeast to humans and provides essential support for the spliceosomal snRNPs (small nuclear ribonucleoproteins). In the present article, we discuss the identification and characterization of the yeast NTC and review recent work in yeast that supports the essential role for this complex in the regulation and fidelity of splicing. ©2010 Biochemical Society.

Original language	English
Pages (from-to)	1110-1115
Number of pages	5
Journal	Biochemical Society Transactions
Volume	38
Issue number	4
DOIs	https://doi.org/10.1042/BST0381110
Publication status	Published - Aug 2010

Keywords

NineTeen Complex (NTC)
Pre-mRNA splicing
Prp19
Spliceosome

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10.1042/BST0381110

http://www.biochemsoctrans.org/bst/038/1110/0381110.pdf

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title = "The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing",

abstract = "The NineTeen Complex (NTC) of proteins associates with the spliceosome during pre-mRNA splicing and is essential for both steps of intron removal. The NTC and other NTC-associated proteins are recruited to the spliceosome where they participate in regulating the formation and progression of essential spliceosome conformations required for the two steps of splicing. It is now clear that the NTC is an integral component of active spliceosomes from yeast to humans and provides essential support for the spliceosomal snRNPs (small nuclear ribonucleoproteins). In the present article, we discuss the identification and characterization of the yeast NTC and review recent work in yeast that supports the essential role for this complex in the regulation and fidelity of splicing. {\textcopyright}2010 Biochemical Society.",

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T1 - The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing

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AU - McGrail, Joanne C.

AU - O'Keefe, Raymond T.

N1 - , Biotechnology and Biological Sciences Research Council, United Kingdom, Wellcome Trust, United Kingdom

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N2 - The NineTeen Complex (NTC) of proteins associates with the spliceosome during pre-mRNA splicing and is essential for both steps of intron removal. The NTC and other NTC-associated proteins are recruited to the spliceosome where they participate in regulating the formation and progression of essential spliceosome conformations required for the two steps of splicing. It is now clear that the NTC is an integral component of active spliceosomes from yeast to humans and provides essential support for the spliceosomal snRNPs (small nuclear ribonucleoproteins). In the present article, we discuss the identification and characterization of the yeast NTC and review recent work in yeast that supports the essential role for this complex in the regulation and fidelity of splicing. ©2010 Biochemical Society.

AB - The NineTeen Complex (NTC) of proteins associates with the spliceosome during pre-mRNA splicing and is essential for both steps of intron removal. The NTC and other NTC-associated proteins are recruited to the spliceosome where they participate in regulating the formation and progression of essential spliceosome conformations required for the two steps of splicing. It is now clear that the NTC is an integral component of active spliceosomes from yeast to humans and provides essential support for the spliceosomal snRNPs (small nuclear ribonucleoproteins). In the present article, we discuss the identification and characterization of the yeast NTC and review recent work in yeast that supports the essential role for this complex in the regulation and fidelity of splicing. ©2010 Biochemical Society.

KW - NineTeen Complex (NTC)

KW - Pre-mRNA splicing

KW - Prp19

KW - Spliceosome

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DO - 10.1042/BST0381110

M3 - Article

C2 - 20659013

SN - 1470-8752

VL - 38

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EP - 1115

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 4

ER -

The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing

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