The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease

Ma C. Martín; J. Oliver; E. Urcelay; G. Orozco; M. Gómez-Garcia; M. Á López-Nevot; A. Piñero; J. A. Brieva; E. G. De La Concha; A. Nieto; Javier Martin

doi:10.1111/j.1399-0039.2005.00428.x

The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease

Ma C. Martín, J. Oliver, E. Urcelay, G. Orozco, M. Gómez-Garcia, M. Á López-Nevot, A. Piñero, J. A. Brieva, E. G. De La Concha, A. Nieto, Javier Martin

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Abstract

The aim of this study was to assess the possible association between the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene 1858→T (rs2476601, encoding R620W) polymorphism and inflammatory bowel disease (IBD). Our study population consisted of 1113 IBD [544 ulcerative colitis (UC) and 569 Crohn's disease (CD)] patients and 812 healthy subjects. All the individuals were of Spanish white origin. Genotyping of the PTPN22 gene 1858C→T polymorphism was performed by real time polymerase chain reaction technology, using TaqMan 5′-allelic discrimination assay. The frequency of the PTPN22 1858T allele in healthy subjects was 6.2% compared with 6.7% in the UC patients and 5.1% in Crohn's patients. No statistically significant differences were observed when the PTPN22 1858C→T allele and genotype distribution among CD patients, UC patients and healthy controls were compared. These results indicate that the PTPN22 1858C→T polymorphism does not appear to play a major role in IBD predisposition in our population. © 2005 Blackwell Publishing Ltd.

Original language	English
Pages (from-to)	314-317
Number of pages	3
Journal	Tissue Antigens
Volume	66
Issue number	4
DOIs	https://doi.org/10.1111/j.1399-0039.2005.00428.x
Publication status	Published - Oct 2005

Keywords

Crohn's disease
Inflammatory bowel disease
Lymphoid-specific phosphatase (LYP)
PTPN22
Ulcerative colitis

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10.1111/j.1399-0039.2005.00428.x

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Martín, M. C., Oliver, J., Urcelay, E., Orozco, G., Gómez-Garcia, M., López-Nevot, M. Á., Piñero, A., Brieva, J. A., De La Concha, E. G., Nieto, A., & Martin, J. (2005). The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease. Tissue Antigens, 66(4), 314-317. https://doi.org/10.1111/j.1399-0039.2005.00428.x

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title = "The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease",

abstract = "The aim of this study was to assess the possible association between the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene 1858→T (rs2476601, encoding R620W) polymorphism and inflammatory bowel disease (IBD). Our study population consisted of 1113 IBD [544 ulcerative colitis (UC) and 569 Crohn's disease (CD)] patients and 812 healthy subjects. All the individuals were of Spanish white origin. Genotyping of the PTPN22 gene 1858C→T polymorphism was performed by real time polymerase chain reaction technology, using TaqMan 5′-allelic discrimination assay. The frequency of the PTPN22 1858T allele in healthy subjects was 6.2% compared with 6.7% in the UC patients and 5.1% in Crohn's patients. No statistically significant differences were observed when the PTPN22 1858C→T allele and genotype distribution among CD patients, UC patients and healthy controls were compared. These results indicate that the PTPN22 1858C→T polymorphism does not appear to play a major role in IBD predisposition in our population. {\textcopyright} 2005 Blackwell Publishing Ltd.",

keywords = "Crohn's disease, Inflammatory bowel disease, Lymphoid-specific phosphatase (LYP), PTPN22, Ulcerative colitis",

author = "Mart{\'i}n, {Ma C.} and J. Oliver and E. Urcelay and G. Orozco and M. G{\'o}mez-Garcia and L{\'o}pez-Nevot, {M. {\'A}} and A. Pi{\~n}ero and Brieva, {J. A.} and {De La Concha}, {E. G.} and A. Nieto and Javier Martin",

year = "2005",

month = oct,

doi = "10.1111/j.1399-0039.2005.00428.x",

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pages = "314--317",

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Martín, MC, Oliver, J, Urcelay, E, Orozco, G, Gómez-Garcia, M, López-Nevot, MÁ, Piñero, A, Brieva, JA, De La Concha, EG, Nieto, A & Martin, J 2005, 'The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease', Tissue Antigens, vol. 66, no. 4, pp. 314-317. https://doi.org/10.1111/j.1399-0039.2005.00428.x

TY - JOUR

T1 - The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease

AU - Martín, Ma C.

AU - Oliver, J.

AU - Urcelay, E.

AU - Orozco, G.

AU - Gómez-Garcia, M.

AU - López-Nevot, M. Á

AU - Piñero, A.

AU - Brieva, J. A.

AU - De La Concha, E. G.

AU - Nieto, A.

AU - Martin, Javier

PY - 2005/10

Y1 - 2005/10

N2 - The aim of this study was to assess the possible association between the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene 1858→T (rs2476601, encoding R620W) polymorphism and inflammatory bowel disease (IBD). Our study population consisted of 1113 IBD [544 ulcerative colitis (UC) and 569 Crohn's disease (CD)] patients and 812 healthy subjects. All the individuals were of Spanish white origin. Genotyping of the PTPN22 gene 1858C→T polymorphism was performed by real time polymerase chain reaction technology, using TaqMan 5′-allelic discrimination assay. The frequency of the PTPN22 1858T allele in healthy subjects was 6.2% compared with 6.7% in the UC patients and 5.1% in Crohn's patients. No statistically significant differences were observed when the PTPN22 1858C→T allele and genotype distribution among CD patients, UC patients and healthy controls were compared. These results indicate that the PTPN22 1858C→T polymorphism does not appear to play a major role in IBD predisposition in our population. © 2005 Blackwell Publishing Ltd.

AB - The aim of this study was to assess the possible association between the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene 1858→T (rs2476601, encoding R620W) polymorphism and inflammatory bowel disease (IBD). Our study population consisted of 1113 IBD [544 ulcerative colitis (UC) and 569 Crohn's disease (CD)] patients and 812 healthy subjects. All the individuals were of Spanish white origin. Genotyping of the PTPN22 gene 1858C→T polymorphism was performed by real time polymerase chain reaction technology, using TaqMan 5′-allelic discrimination assay. The frequency of the PTPN22 1858T allele in healthy subjects was 6.2% compared with 6.7% in the UC patients and 5.1% in Crohn's patients. No statistically significant differences were observed when the PTPN22 1858C→T allele and genotype distribution among CD patients, UC patients and healthy controls were compared. These results indicate that the PTPN22 1858C→T polymorphism does not appear to play a major role in IBD predisposition in our population. © 2005 Blackwell Publishing Ltd.

KW - Crohn's disease

KW - Inflammatory bowel disease

KW - Lymphoid-specific phosphatase (LYP)

KW - PTPN22

KW - Ulcerative colitis

U2 - 10.1111/j.1399-0039.2005.00428.x

DO - 10.1111/j.1399-0039.2005.00428.x

M3 - Article

SN - 0001-2815

VL - 66

SP - 314

EP - 317

JO - Tissue Antigens

JF - Tissue Antigens

IS - 4

ER -

The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease

Abstract

Keywords

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