TY - JOUR
T1 - The Fungal and Bacterial Interface in the Respiratory Mycobiome with a Focus on Aspergillus spp.
AU - Rozaliyani, Anna
AU - Antariksa, Budhi
AU - Nurwidya, Fariz
AU - Zaini, Jamal
AU - Setianingrum, Findra
AU - Hasan, Firman
AU - Nugrahapraja, Husna
AU - Yusva, Humaira
AU - Wibowo, Heri
AU - Bowolaksono, Anom
AU - Kosmidis, Chris
N1 - Funding Information:
This research was partly funded by Kemenristek/BRIN with a grant number NKB-2883/UN2.RST/HKP.05.00/2020.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/4/14
Y1 - 2023/4/14
N2 - The heterogeneity of the lung microbiome and its alteration are prevalently seen among chronic lung diseases patients. However, studies to date have primarily focused on the bacterial microbiome in the lung rather than fungal composition, which might play an essential role in the mechanisms of several chronic lung diseases. It is now well established that Aspergillus spp. colonies may induce various unfavorable inflammatory responses. Furthermore, bacterial microbiomes such as Pseudomonas aeruginosa provide several mechanisms that inhibit or stimulate Aspergillus spp. life cycles. In this review, we highlighted fungal and bacterial microbiome interactions in the respiratory tract, with a focus on Aspergillus spp.
AB - The heterogeneity of the lung microbiome and its alteration are prevalently seen among chronic lung diseases patients. However, studies to date have primarily focused on the bacterial microbiome in the lung rather than fungal composition, which might play an essential role in the mechanisms of several chronic lung diseases. It is now well established that Aspergillus spp. colonies may induce various unfavorable inflammatory responses. Furthermore, bacterial microbiomes such as Pseudomonas aeruginosa provide several mechanisms that inhibit or stimulate Aspergillus spp. life cycles. In this review, we highlighted fungal and bacterial microbiome interactions in the respiratory tract, with a focus on Aspergillus spp.
KW - Aspergillusspp
KW - chronic lung diseases
KW - immunological response
KW - lung mycobiome
UR - http://www.scopus.com/inward/record.url?scp=85156101162&partnerID=8YFLogxK
U2 - 10.3390/life13041017
DO - 10.3390/life13041017
M3 - Article
C2 - 37109545
AN - SCOPUS:85156101162
SN - 2075-1729
VL - 13
JO - Life
JF - Life
IS - 4
M1 - 1017
ER -