The Fungal and Bacterial Interface in the Respiratory Mycobiome with a Focus on Aspergillus spp.

Anna Rozaliyani, Budhi Antariksa, Fariz Nurwidya, Jamal Zaini, Findra Setianingrum, Firman Hasan, Husna Nugrahapraja, Humaira Yusva, Heri Wibowo, Anom Bowolaksono, Chris Kosmidis

Research output: Contribution to journalArticlepeer-review


The heterogeneity of the lung microbiome and its alteration are prevalently seen among chronic lung diseases patients. However, studies to date have primarily focused on the bacterial microbiome in the lung rather than fungal composition, which might play an essential role in the mechanisms of several chronic lung diseases. It is now well established that Aspergillus spp. colonies may induce various unfavorable inflammatory responses. Furthermore, bacterial microbiomes such as Pseudomonas aeruginosa provide several mechanisms that inhibit or stimulate Aspergillus spp. life cycles. In this review, we highlighted fungal and bacterial microbiome interactions in the respiratory tract, with a focus on Aspergillus spp.

Original languageEnglish
Article number1017
Issue number4
Publication statusPublished - 14 Apr 2023


  • Aspergillusspp
  • chronic lung diseases
  • immunological response
  • lung mycobiome


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