The gel electrophoresis markup language (GelML) from the proteomics standards initiative

Frank Gibson, Christine Hoogland, Salvador Martinez-Bartolomé, J. Alberto Medina-Aunon, Juan Pablo Albar, Gyorgy Babnigg, Anil Wipat, Henning Hermjakob, Jonas S. Almeida, Romesh Stanislaus, Norman W. Paton, Andrew R. Jones

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The Human Proteome Organisation's Proteomics Standards Initiative has developed the GelML (gel electrophoresis markup language) data exchange format for representing gel electrophoresis experiments performed in proteomics investigations. The format closely follows the reporting guidelines for gel electrophoresis, which are part of the Minimum Information About a Proteomics Experiment (MIAPE) set of modules. GelML supports the capture of metadata (such as experimental protocols) and data (such as gel images) resulting from gel electrophoresis so that laboratories can be compliant with the MIAPE Gel Electrophoresis guidelines, while allowing such data sets to be exchanged or downloaded from public repositories. The format is sufficiently flexible to capture data from a broad range of experimental processes, and complements other PSI formats for MS data and the results of protein and peptide identifications to capture entire gel-based proteome workflows. GelML has resulted from the open standardisation process of PSI consisting of both public consultation and anonymous review of the specifications. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
    Original languageEnglish
    Pages (from-to)3073-3081
    Number of pages8
    JournalProteomics
    Volume10
    Issue number17
    DOIs
    Publication statusPublished - Sept 2010

    Keywords

    • Bioinformatics
    • Data standard
    • Database
    • Gel electrophoresis
    • Ontology

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