The genetic contribution to severe post-traumatic osteoarthritis

A M Valdes; S A Doherty; K R Muir; M Wheeler; R A Maciewicz; W Zhang; M Doherty

doi:10.1136/annrheumdis-2012-202562

The genetic contribution to severe post-traumatic osteoarthritis

A M Valdes, S A Doherty, K R Muir, M Wheeler, R A Maciewicz, W Zhang, M Doherty

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement. METHODS: A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were genotyped for 12 variants previously reported to be reproducibly associated with risk of knee or hip OA. A genetic risk score was generated and the association with PT and NT TKR and THR was assessed adjusting for covariates. RESULTS: For THR, each additional genetic risk variant conferred lower risk among PT cases (OR=1.07, 95% CI 0.96 to 1.19; p=0.24) than NT cases (OR 1.11, 95% CI 1.06 to 1.17; p=1.55x10(-5)). In contrast, for TKR, each risk variant conferred slightly higher risk among PT cases (OR 1.12, 95% CI 1.07 to 1.19; p=1.82x10(-5)) than among NT cases (OR 1.08, 95% CI 1.03 to 1.1; p=0.00063). CONCLUSIONS: Based on the variants reported to date PT TKR cases have at least as high a genetic contribution as NT cases.

Original language	English
Journal	Ann Rheum Dis
DOIs	https://doi.org/10.1136/annrheumdis-2012-202562
Publication status	Published - 2013

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@article{fde55e089fe54ba3b0636052c5735af5,

title = "The genetic contribution to severe post-traumatic osteoarthritis",

abstract = "OBJECTIVE: To compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement. METHODS: A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were genotyped for 12 variants previously reported to be reproducibly associated with risk of knee or hip OA. A genetic risk score was generated and the association with PT and NT TKR and THR was assessed adjusting for covariates. RESULTS: For THR, each additional genetic risk variant conferred lower risk among PT cases (OR=1.07, 95% CI 0.96 to 1.19; p=0.24) than NT cases (OR 1.11, 95% CI 1.06 to 1.17; p=1.55x10(-5)). In contrast, for TKR, each risk variant conferred slightly higher risk among PT cases (OR 1.12, 95% CI 1.07 to 1.19; p=1.82x10(-5)) than among NT cases (OR 1.08, 95% CI 1.03 to 1.1; p=0.00063). CONCLUSIONS: Based on the variants reported to date PT TKR cases have at least as high a genetic contribution as NT cases.",

author = "Valdes, {A M} and Doherty, {S A} and Muir, {K R} and M Wheeler and Maciewicz, {R A} and W Zhang and M Doherty",

note = "Valdes, Ana M Doherty, Sally A Muir, Kenneth R Wheeler, Margaret Maciewicz, Rose A Zhang, Weiya Doherty, Michael Annals of the rheumatic diseases Ann Rheum Dis. 2013 Jan 26.",

year = "2013",

doi = "10.1136/annrheumdis-2012-202562",

language = "English",

journal = "Ann Rheum Dis",

issn = "0003-4967",

publisher = "BMJ ",

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TY - JOUR

T1 - The genetic contribution to severe post-traumatic osteoarthritis

AU - Valdes, A M

AU - Doherty, S A

AU - Muir, K R

AU - Wheeler, M

AU - Maciewicz, R A

AU - Zhang, W

AU - Doherty, M

N1 - Valdes, Ana M Doherty, Sally A Muir, Kenneth R Wheeler, Margaret Maciewicz, Rose A Zhang, Weiya Doherty, Michael Annals of the rheumatic diseases Ann Rheum Dis. 2013 Jan 26.

PY - 2013

Y1 - 2013

N2 - OBJECTIVE: To compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement. METHODS: A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were genotyped for 12 variants previously reported to be reproducibly associated with risk of knee or hip OA. A genetic risk score was generated and the association with PT and NT TKR and THR was assessed adjusting for covariates. RESULTS: For THR, each additional genetic risk variant conferred lower risk among PT cases (OR=1.07, 95% CI 0.96 to 1.19; p=0.24) than NT cases (OR 1.11, 95% CI 1.06 to 1.17; p=1.55x10(-5)). In contrast, for TKR, each risk variant conferred slightly higher risk among PT cases (OR 1.12, 95% CI 1.07 to 1.19; p=1.82x10(-5)) than among NT cases (OR 1.08, 95% CI 1.03 to 1.1; p=0.00063). CONCLUSIONS: Based on the variants reported to date PT TKR cases have at least as high a genetic contribution as NT cases.

AB - OBJECTIVE: To compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement. METHODS: A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were genotyped for 12 variants previously reported to be reproducibly associated with risk of knee or hip OA. A genetic risk score was generated and the association with PT and NT TKR and THR was assessed adjusting for covariates. RESULTS: For THR, each additional genetic risk variant conferred lower risk among PT cases (OR=1.07, 95% CI 0.96 to 1.19; p=0.24) than NT cases (OR 1.11, 95% CI 1.06 to 1.17; p=1.55x10(-5)). In contrast, for TKR, each risk variant conferred slightly higher risk among PT cases (OR 1.12, 95% CI 1.07 to 1.19; p=1.82x10(-5)) than among NT cases (OR 1.08, 95% CI 1.03 to 1.1; p=0.00063). CONCLUSIONS: Based on the variants reported to date PT TKR cases have at least as high a genetic contribution as NT cases.

U2 - 10.1136/annrheumdis-2012-202562

DO - 10.1136/annrheumdis-2012-202562

M3 - Article

SN - 0003-4967

JO - Ann Rheum Dis

JF - Ann Rheum Dis

ER -

The genetic contribution to severe post-traumatic osteoarthritis

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