The Genomics Revolution and Radiotherapy

C. M L West; R. M. Elliott; N. G. Burnet

doi:10.1016/j.clon.2007.02.016

The Genomics Revolution and Radiotherapy

C. M L West, R. M. Elliott, N. G. Burnet

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

The expansion of our knowledge through the Human Genome Project has been accompanied by the development of new high-throughput techniques, which provide extensive capabilities for the analysis of a large number of genes or the whole genome. These assays can be carried out in various clinical samples at the DNA (genome), RNA (transcriptome) or protein (proteome) level. There is a belief that this genomic revolution, i.e. sequencing of the human genome and developments in high-throughput technology, heralds a future of personalised medicine. For clinical oncology, this progress should increase the possibility of predicting individual patient responses to radiotherapy. This review highlights some of the work involving sparsely ionising radiation and the new technologies. © 2007 The Royal College of Radiologists.

Original language	English
Pages (from-to)	470-480
Number of pages	10
Journal	Clinical Oncology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.clon.2007.02.016
Publication status	Published - Aug 2007

Keywords

Genomics
predictive assays
radiobiology

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10.1016/j.clon.2007.02.016

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abstract = "The expansion of our knowledge through the Human Genome Project has been accompanied by the development of new high-throughput techniques, which provide extensive capabilities for the analysis of a large number of genes or the whole genome. These assays can be carried out in various clinical samples at the DNA (genome), RNA (transcriptome) or protein (proteome) level. There is a belief that this genomic revolution, i.e. sequencing of the human genome and developments in high-throughput technology, heralds a future of personalised medicine. For clinical oncology, this progress should increase the possibility of predicting individual patient responses to radiotherapy. This review highlights some of the work involving sparsely ionising radiation and the new technologies. {\textcopyright} 2007 The Royal College of Radiologists.",

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AU - Elliott, R. M.

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AB - The expansion of our knowledge through the Human Genome Project has been accompanied by the development of new high-throughput techniques, which provide extensive capabilities for the analysis of a large number of genes or the whole genome. These assays can be carried out in various clinical samples at the DNA (genome), RNA (transcriptome) or protein (proteome) level. There is a belief that this genomic revolution, i.e. sequencing of the human genome and developments in high-throughput technology, heralds a future of personalised medicine. For clinical oncology, this progress should increase the possibility of predicting individual patient responses to radiotherapy. This review highlights some of the work involving sparsely ionising radiation and the new technologies. © 2007 The Royal College of Radiologists.

KW - Genomics

KW - predictive assays

KW - radiobiology

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SP - 470

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JO - Clinical Oncology

JF - Clinical Oncology

IS - 6

ER -

The Genomics Revolution and Radiotherapy

Abstract

Keywords

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