The Hitchhiker's Guide across a Waddington's landscape of melanoma

Kerrie L Marie, Glenn Merlino, Chi-Ping Day

Research output: Contribution to journalComment/debatepeer-review


Melanoma evolution may recapitulate the embryonic development of its progenitor tissue, neural crest (NC), but the exact process is unclear. In a recent issue of Nature, Karras et al. (2022) demonstrate that melanoma expansion mirrors the hierarchic process of NC differentiation, generating cell subpopulations, each with distinct function, including growth and metastasis.

Original languageEnglish
Pages (from-to)2447-2449
Number of pages3
JournalDevelopmental cell
Issue number21
Publication statusPublished - 7 Nov 2022


  • Humans
  • Cell Differentiation
  • Melanoma
  • Neural Crest
  • Organogenesis


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