The Hitchhiker's Guide across a Waddington's landscape of melanoma

Kerrie L Marie; Glenn Merlino; Chi-Ping Day

doi:10.1016/j.devcel.2022.10.005

The Hitchhiker's Guide across a Waddington's landscape of melanoma

Kerrie L Marie, Glenn Merlino, Chi-Ping Day

Division of Molecular & Cellular Function (L5)

National Cancer Institute

Research output: Contribution to journal › Commentary/debate › peer-review

Abstract

Melanoma evolution may recapitulate the embryonic development of its progenitor tissue, neural crest (NC), but the exact process is unclear. In a recent issue of Nature, Karras et al. (2022) demonstrate that melanoma expansion mirrors the hierarchic process of NC differentiation, generating cell subpopulations, each with distinct function, including growth and metastasis.

Original language	English
Pages (from-to)	2447-2449
Number of pages	3
Journal	Developmental cell
Volume	57
Issue number	21
DOIs	https://doi.org/10.1016/j.devcel.2022.10.005
Publication status	Published - 7 Nov 2022

Keywords

Humans
Cell Differentiation
Melanoma
Neural Crest
Organogenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.devcel.2022.10.005

Cite this

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title = "The Hitchhiker's Guide across a Waddington's landscape of melanoma",

abstract = "Melanoma evolution may recapitulate the embryonic development of its progenitor tissue, neural crest (NC), but the exact process is unclear. In a recent issue of Nature, Karras et al. (2022) demonstrate that melanoma expansion mirrors the hierarchic process of NC differentiation, generating cell subpopulations, each with distinct function, including growth and metastasis.",

keywords = "Humans, Cell Differentiation, Melanoma, Neural Crest, Organogenesis",

author = "Marie, {Kerrie L} and Glenn Merlino and Chi-Ping Day",

note = "Funding Information: The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

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AU - Marie, Kerrie L

AU - Merlino, Glenn

AU - Day, Chi-Ping

PY - 2022/11/7

Y1 - 2022/11/7

N2 - Melanoma evolution may recapitulate the embryonic development of its progenitor tissue, neural crest (NC), but the exact process is unclear. In a recent issue of Nature, Karras et al. (2022) demonstrate that melanoma expansion mirrors the hierarchic process of NC differentiation, generating cell subpopulations, each with distinct function, including growth and metastasis.

AB - Melanoma evolution may recapitulate the embryonic development of its progenitor tissue, neural crest (NC), but the exact process is unclear. In a recent issue of Nature, Karras et al. (2022) demonstrate that melanoma expansion mirrors the hierarchic process of NC differentiation, generating cell subpopulations, each with distinct function, including growth and metastasis.

KW - Humans

KW - Cell Differentiation

KW - Melanoma

KW - Neural Crest

KW - Organogenesis

U2 - 10.1016/j.devcel.2022.10.005

DO - 10.1016/j.devcel.2022.10.005

M3 - Commentary/debate

C2 - 36347238

SN - 1534-5807

VL - 57

SP - 2447

EP - 2449

JO - Developmental cell

JF - Developmental cell

IS - 21

ER -

The Hitchhiker's Guide across a Waddington's landscape of melanoma

Abstract

Keywords

UN SDGs

Access to Document

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Cite this