The hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines

Ursula Just; On Kan; Jan Fennelly; T. Michael Dexter; Elaine Spooncer

doi:10.3109/08977199509036877

The hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines

Ursula Just, On Kan, Jan Fennelly, T. Michael Dexter, Elaine Spooncer

Research output: Contribution to journal › Article › peer-review

Abstract

The establishment of IL-3-dependent multipotent progenitor cell lines from Hox-2.4-expressing bone marrow cells suggests that homeobox genes may contribute to immortalization of early myeloid cells. A survey of 20 independently derived multipotent IL-3-dependent cell lines established from either src-virus-infected long-term bone marrow cultures (FDCP-mix) or Multi-CSF-virus (M3MuV)-infected bone marrow revealed that Hox-2.4 was not expressed in any of these cell lines. In addition DNA rearrangements were not observed. We conclude that activation of Hox-2.4 is not an obligatory event in the immortalization of early myeloid cells. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Original language	English
Pages (from-to)	173-177
Number of pages	4
Journal	Growth Factors
Volume	12
Issue number	3
DOIs	https://doi.org/10.3109/08977199509036877
Publication status	Published - 1995

Keywords

FDCP-mix
Hox2.4

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/08977199509036877

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title = "The hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines",

abstract = "The establishment of IL-3-dependent multipotent progenitor cell lines from Hox-2.4-expressing bone marrow cells suggests that homeobox genes may contribute to immortalization of early myeloid cells. A survey of 20 independently derived multipotent IL-3-dependent cell lines established from either src-virus-infected long-term bone marrow cultures (FDCP-mix) or Multi-CSF-virus (M3MuV)-infected bone marrow revealed that Hox-2.4 was not expressed in any of these cell lines. In addition DNA rearrangements were not observed. We conclude that activation of Hox-2.4 is not an obligatory event in the immortalization of early myeloid cells. {\textcopyright} 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.",

keywords = "FDCP-mix, Hox2.4",

author = "Ursula Just and On Kan and Jan Fennelly and Dexter, {T. Michael} and Elaine Spooncer",

year = "1995",

doi = "10.3109/08977199509036877",

language = "English",

volume = "12",

pages = "173--177",

journal = "Growth Factors",

issn = "1029-2292",

publisher = "Informa Healthcare",

number = "3",

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TY - JOUR

T1 - The hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines

AU - Just, Ursula

AU - Kan, On

AU - Fennelly, Jan

AU - Dexter, T. Michael

AU - Spooncer, Elaine

PY - 1995

Y1 - 1995

N2 - The establishment of IL-3-dependent multipotent progenitor cell lines from Hox-2.4-expressing bone marrow cells suggests that homeobox genes may contribute to immortalization of early myeloid cells. A survey of 20 independently derived multipotent IL-3-dependent cell lines established from either src-virus-infected long-term bone marrow cultures (FDCP-mix) or Multi-CSF-virus (M3MuV)-infected bone marrow revealed that Hox-2.4 was not expressed in any of these cell lines. In addition DNA rearrangements were not observed. We conclude that activation of Hox-2.4 is not an obligatory event in the immortalization of early myeloid cells. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

AB - The establishment of IL-3-dependent multipotent progenitor cell lines from Hox-2.4-expressing bone marrow cells suggests that homeobox genes may contribute to immortalization of early myeloid cells. A survey of 20 independently derived multipotent IL-3-dependent cell lines established from either src-virus-infected long-term bone marrow cultures (FDCP-mix) or Multi-CSF-virus (M3MuV)-infected bone marrow revealed that Hox-2.4 was not expressed in any of these cell lines. In addition DNA rearrangements were not observed. We conclude that activation of Hox-2.4 is not an obligatory event in the immortalization of early myeloid cells. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

KW - FDCP-mix

KW - Hox2.4

U2 - 10.3109/08977199509036877

DO - 10.3109/08977199509036877

M3 - Article

C2 - 8619923

SN - 1029-2292

VL - 12

SP - 173

EP - 177

JO - Growth Factors

JF - Growth Factors

IS - 3

ER -

The hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines

Abstract

Keywords

UN SDGs

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