The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4

T Bonner, S J O'Brien, W G Nash, U R Rapp, C C Morton, P Leder

Research output: Contribution to journalArticlepeer-review

Abstract

Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies.

Original languageEnglish
Pages (from-to)71-4
Number of pages4
JournalScience
Volume223
Issue number4631
Publication statusPublished - 6 Jan 1984

Keywords

  • Adenocarcinoma
  • Animals
  • Chromosome Aberrations
  • Chromosome Mapping
  • Chromosomes, Human, 1-3
  • Chromosomes, Human, 4-5
  • Cricetinae
  • Humans
  • Hybrid Cells
  • Kidney Neoplasms
  • Lung Neoplasms
  • Male
  • Mice
  • Nucleic Acid Hybridization
  • Oncogenes
  • Journal Article

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