TY - JOUR
T1 - The identification of a complex A/G/I/J recombinant HIV type 1 virus in various West African countries
AU - Montavon, Celine
AU - Bibollet-Ruche, Frederic
AU - Robertson, David
AU - Koumare, Brahim
AU - Mulanga, Claire
AU - Esu-Williams, Eka
AU - Toure, Coumba
AU - Mboup, Souleymane
AU - Saman, Eric
AU - Delaporte, Eric
AU - Peeters, Martine
PY - 1999/12/10
Y1 - 1999/12/10
N2 - In this sequence note we describe the full-length genome sequence of an HIV-1 isolate originating from the west African country of Mali. The phylogenetic tree analysis from the near full-length genome shows that the 95ML84 strain forms a separate cluster, supported by 100% of the bootstrap values, with the previously described A/G/J/? mosaic virus BFP90 from Burkina Faso. Additional analysis showed that throughout the genome the lowest diversity was seen between the 95ML84 and the BFP90 viruses, and bootscan analysis showed a similar complex genomic structure. In addition to the initial report describing the BFP90 virus as an A/G/J/? recombinant, our data show that for the BFP90 and 95ML84 strains the unclassified region corresponds to subtype I. The A/G/I/J BFP90 and 95ML84 strains represent the fifth and most complex circulating recombinant form of HIV-1 detected so far, and our data show its presence in various West African countries. Subtype I and J sequences, initially considered rare, seem to have broadened their geographical spread by way of these recombinant forms.
AB - In this sequence note we describe the full-length genome sequence of an HIV-1 isolate originating from the west African country of Mali. The phylogenetic tree analysis from the near full-length genome shows that the 95ML84 strain forms a separate cluster, supported by 100% of the bootstrap values, with the previously described A/G/J/? mosaic virus BFP90 from Burkina Faso. Additional analysis showed that throughout the genome the lowest diversity was seen between the 95ML84 and the BFP90 viruses, and bootscan analysis showed a similar complex genomic structure. In addition to the initial report describing the BFP90 virus as an A/G/J/? recombinant, our data show that for the BFP90 and 95ML84 strains the unclassified region corresponds to subtype I. The A/G/I/J BFP90 and 95ML84 strains represent the fifth and most complex circulating recombinant form of HIV-1 detected so far, and our data show its presence in various West African countries. Subtype I and J sequences, initially considered rare, seem to have broadened their geographical spread by way of these recombinant forms.
U2 - 10.1089/088922299309757
DO - 10.1089/088922299309757
M3 - Article
SN - 0889-2229
VL - 15
SP - 1707
EP - 1712
JO - AIDS research and human retroviruses
JF - AIDS research and human retroviruses
IS - 18
ER -