The identification of a complex A/G/I/J recombinant HIV type 1 virus in various West African countries

Celine Montavon, Frederic Bibollet-Ruche, David Robertson, Brahim Koumare, Claire Mulanga, Eka Esu-Williams, Coumba Toure, Souleymane Mboup, Eric Saman, Eric Delaporte, Martine Peeters

    Research output: Contribution to journalArticlepeer-review


    In this sequence note we describe the full-length genome sequence of an HIV-1 isolate originating from the west African country of Mali. The phylogenetic tree analysis from the near full-length genome shows that the 95ML84 strain forms a separate cluster, supported by 100% of the bootstrap values, with the previously described A/G/J/? mosaic virus BFP90 from Burkina Faso. Additional analysis showed that throughout the genome the lowest diversity was seen between the 95ML84 and the BFP90 viruses, and bootscan analysis showed a similar complex genomic structure. In addition to the initial report describing the BFP90 virus as an A/G/J/? recombinant, our data show that for the BFP90 and 95ML84 strains the unclassified region corresponds to subtype I. The A/G/I/J BFP90 and 95ML84 strains represent the fifth and most complex circulating recombinant form of HIV-1 detected so far, and our data show its presence in various West African countries. Subtype I and J sequences, initially considered rare, seem to have broadened their geographical spread by way of these recombinant forms.
    Original languageEnglish
    Pages (from-to)1707-1712
    Number of pages5
    JournalAIDS research and human retroviruses
    Issue number18
    Publication statusPublished - 10 Dec 1999


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