The IGF axis and placental function: A mini review

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    Abstract

    It is well known that the insulin-like growth factor (IGF) axis is an important regulator of foetal growth and in recent years, it has been suggested that the ligands IGF-I and IGF-II may, in part, mediate this effect by promoting proper placental development and function. In other tissues, IGF effects on metabolism, proliferation and differentiation are primarily mediated via IGF binding protein-regulated interaction of IGFs with the type 1 IGF receptor and therefore here, we review the placental expression and postulated role, of each of the IGF axis components and discuss the cellular mechanisms through which these effects are exerted. Copyright © 2008 S. Karger AG.
    Original languageEnglish
    Pages (from-to)129-137
    Number of pages8
    JournalHormone Research
    Volume69
    Issue number3
    DOIs
    Publication statusPublished - Jan 2008

    Keywords

    • Apoptosis
    • Differentiation
    • Insulin-like growth factor
    • Insulin-like growth factor binding protein
    • Migration
    • Mitogen-activated protein kinase
    • PI3K
    • Placenta
    • Proliferation

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