The IGF axis in HPV associated cancers

Adam Pickard, Julia Durzynska, Dennis J. McCance, Elisabeth R. Barton

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract Human papillomaviruses (HPV) infect and replicate in stratified epithelium at cutaneous and mucosal surfaces. The proliferation and maintenance of keratinocytes, the cells which make up this epithelium, are controlled by a number of growth factor receptors such as the keratinocyte growth factor receptor (KGFR, also called fibroblast growth factor receptor 2b (FGFR2b)), the epithelial growth factor receptor (EGFR) and the insulin-like growth factor receptors 1 and 2 (IGF1R and IGF2R). In this review, we will delineate the mutation, gene transcription, translation and processing of the IGF axis within HPV associated cancers. The IGFs are key for developmental and postnatal growth of almost all tissues; we explore whether this crucial axis has been hijacked by HPV.
Original languageEnglish
JournalMutation Research - Reviews
Early online date4 Feb 2017
DOIs
Publication statusPublished - 2017

Keywords

  • HPV
  • IGF-I
  • IGF-II
  • IGF1R
  • IGF2R
  • Cancer

Fingerprint

Dive into the research topics of 'The IGF axis in HPV associated cancers'. Together they form a unique fingerprint.

Cite this