The Immune Responses to Alloantigens

Graham Lord; Robert I.  Lechler

doi:10.1201/9780203909508

The Immune Responses to Alloantigens

Graham Lord, Robert I. Lechler

FBMH Faculty Office Administration (L5)

Imperial College London

Research output: Chapter in Book/Conference proceeding › Chapter › peer-review

Abstract

Tissues that are mismatched for major histocompatibility complex (MHC) molecules can induce uniquely strong primary immune responses in vitro, as reflected by the mixed lymphocyte reaction (MLR), and provoke allograft rejection, graftversus-host disease (GVHD), and the graft-versus-leukemia effect (GVL) in vivo. In fact, the investigation of the targets of the immune responses to allografts led to the discovery of MHC molecules, which were initially called transplantation antigens.

Original language	English
Title of host publication	Allogeneic Immunotherapy for Malignant Diseases
Editors	John Barrett, Yin-Zhen Jiang
Place of Publication	Boca Ranton
Publisher	CRC Press
Chapter	2
Number of pages	26
Edition	1st
ISBN (Electronic)	9780429221903
DOIs	https://doi.org/10.1201/9780203909508
Publication status	Published - 27 Jan 2000

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AB - Tissues that are mismatched for major histocompatibility complex (MHC) molecules can induce uniquely strong primary immune responses in vitro, as reflected by the mixed lymphocyte reaction (MLR), and provoke allograft rejection, graftversus-host disease (GVHD), and the graft-versus-leukemia effect (GVL) in vivo. In fact, the investigation of the targets of the immune responses to allografts led to the discovery of MHC molecules, which were initially called transplantation antigens.

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A2 - Jiang, Yin-Zhen

PB - CRC Press

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ER -

The Immune Responses to Alloantigens

Abstract

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