The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

Martin J. Hoogduijn, Felix Popp, Richard Verbeek, Mojgan Masoodi, Anna Nicolaou, Carla Baan, Marc H. Dahlke

    Research output: Contribution to journalArticlepeer-review


    There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless, the immunomodulatory effects of MSC are only partly understood. Clinical trials that are supported by basic research will lead to better understanding of the potential of MSC for immunomodulatory applications and to optimization of such therapies. In this manuscript we review some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models, present new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins by MSC under resting and inflammatory conditions and discuss the hopes and expectations of MSC-based immune therapy. © 2010 Elsevier B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)1496-1500
    Number of pages4
    JournalInternational immunopharmacology
    Issue number12
    Publication statusPublished - Dec 2010


    • Cytokines
    • Immune therapy
    • Immunomodulation
    • Mesenchymal stem cells
    • Organ transplantation
    • Prostaglandins


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