The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

Martin J. Hoogduijn; Felix Popp; Richard Verbeek; Mojgan Masoodi; Anna Nicolaou; Carla Baan; Marc H. Dahlke

doi:10.1016/j.intimp.2010.06.019

The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

Martin J. Hoogduijn, Felix Popp, Richard Verbeek, Mojgan Masoodi, Anna Nicolaou, Carla Baan, Marc H. Dahlke

Research output: Contribution to journal › Article › peer-review

Abstract

There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless, the immunomodulatory effects of MSC are only partly understood. Clinical trials that are supported by basic research will lead to better understanding of the potential of MSC for immunomodulatory applications and to optimization of such therapies. In this manuscript we review some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models, present new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins by MSC under resting and inflammatory conditions and discuss the hopes and expectations of MSC-based immune therapy. © 2010 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	1496-1500
Number of pages	4
Journal	International immunopharmacology
Volume	10
Issue number	12
DOIs	https://doi.org/10.1016/j.intimp.2010.06.019
Publication status	Published - Dec 2010

Keywords

Cytokines
Immune therapy
Immunomodulation
Mesenchymal stem cells
Organ transplantation
Prostaglandins

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10.1016/j.intimp.2010.06.019

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title = "The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy",

abstract = "There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless, the immunomodulatory effects of MSC are only partly understood. Clinical trials that are supported by basic research will lead to better understanding of the potential of MSC for immunomodulatory applications and to optimization of such therapies. In this manuscript we review some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models, present new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins by MSC under resting and inflammatory conditions and discuss the hopes and expectations of MSC-based immune therapy. {\textcopyright} 2010 Elsevier B.V. All rights reserved.",

keywords = "Cytokines, Immune therapy, Immunomodulation, Mesenchymal stem cells, Organ transplantation, Prostaglandins",

author = "Hoogduijn, {Martin J.} and Felix Popp and Richard Verbeek and Mojgan Masoodi and Anna Nicolaou and Carla Baan and Dahlke, {Marc H.}",

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T1 - The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

AU - Hoogduijn, Martin J.

AU - Popp, Felix

AU - Verbeek, Richard

AU - Masoodi, Mojgan

AU - Nicolaou, Anna

AU - Baan, Carla

AU - Dahlke, Marc H.

PY - 2010/12

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N2 - There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless, the immunomodulatory effects of MSC are only partly understood. Clinical trials that are supported by basic research will lead to better understanding of the potential of MSC for immunomodulatory applications and to optimization of such therapies. In this manuscript we review some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models, present new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins by MSC under resting and inflammatory conditions and discuss the hopes and expectations of MSC-based immune therapy. © 2010 Elsevier B.V. All rights reserved.

AB - There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless, the immunomodulatory effects of MSC are only partly understood. Clinical trials that are supported by basic research will lead to better understanding of the potential of MSC for immunomodulatory applications and to optimization of such therapies. In this manuscript we review some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models, present new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins by MSC under resting and inflammatory conditions and discuss the hopes and expectations of MSC-based immune therapy. © 2010 Elsevier B.V. All rights reserved.

KW - Cytokines

KW - Immune therapy

KW - Immunomodulation

KW - Mesenchymal stem cells

KW - Organ transplantation

KW - Prostaglandins

U2 - 10.1016/j.intimp.2010.06.019

DO - 10.1016/j.intimp.2010.06.019

M3 - Article

C2 - 20619384

SN - 1878-1705

VL - 10

SP - 1496

EP - 1500

JO - International immunopharmacology

JF - International immunopharmacology

IS - 12

ER -

The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

Abstract

Keywords

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