TY - JOUR
T1 - The impact of fatigue and psychosocial variables on quality of life for patients with motor neurone disease
AU - Gibbons, Chris
AU - Thornton, Everard W.
AU - Ealing, J.
AU - Shaw, Pamela
AU - Talbot, Kevin
AU - Tennant, Alan
AU - Young, Carolyn
PY - 2013
Y1 - 2013
N2 - AbstractObjectiveTo evaluate the direct and indirect relationships between psychosocial variables, fatigue and quality of life for patients with motor neurone disease (MND). MethodsA cross-sectional sample of 147 MND patients were recruited from five neurological care centres in England. Variables included anxiety, coping, depression, fatigue, functional status, social withdrawal and quality of life. Direct and indirect relationships between study variables were assessed using structural equation modelling (SEM), using linear values derived from Rasch analyses of study questionnaires. ResultsFollowing some modification, Rasch analysis confirmed the suitability of all measures for use in this population. The final SEM model consisting of anxiety, coping, depression, fatigue, social withdrawal and quality of life showed excellent fit to the data. The model accounted for 59% of the variance in quality of life and 50% of the variance in depression. ConclusionsOur data supports a model that explains a large degree of the variance in quality of life for MND patients. Coping was most strongly related to quality of life, with the largest proportion of its influence mediated by anxiety and depression. Significant direct effects upon quality of life were exhibited by depression, fatigue and social withdrawal.
AB - AbstractObjectiveTo evaluate the direct and indirect relationships between psychosocial variables, fatigue and quality of life for patients with motor neurone disease (MND). MethodsA cross-sectional sample of 147 MND patients were recruited from five neurological care centres in England. Variables included anxiety, coping, depression, fatigue, functional status, social withdrawal and quality of life. Direct and indirect relationships between study variables were assessed using structural equation modelling (SEM), using linear values derived from Rasch analyses of study questionnaires. ResultsFollowing some modification, Rasch analysis confirmed the suitability of all measures for use in this population. The final SEM model consisting of anxiety, coping, depression, fatigue, social withdrawal and quality of life showed excellent fit to the data. The model accounted for 59% of the variance in quality of life and 50% of the variance in depression. ConclusionsOur data supports a model that explains a large degree of the variance in quality of life for MND patients. Coping was most strongly related to quality of life, with the largest proportion of its influence mediated by anxiety and depression. Significant direct effects upon quality of life were exhibited by depression, fatigue and social withdrawal.
KW - Quality of life, Rasch analysis, Structural Equation Modelling, Structural Equation Modeling
M3 - Article
SN - 2167-9223
VL - In press
JO - Amyotrophic lateral sclerosis and frontotemporal degeneration
JF - Amyotrophic lateral sclerosis and frontotemporal degeneration
ER -