The impact of screening and genetic registration on mortality and colorectal cancer incidence in familial adenomatous polyposis

E. K L Mallinson, Katherine F. Newton, J. Bowen, F. Lalloo, T. Clancy, J. Hill, D. Gareth R Evans

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: Regular colonic surveillance of familial adenomatous polyposis (FAP) patients is necessary to ensure appropriate prophylactic surgery is performed before colorectal cancer (CRC) develops. Polyposis Registries have been established to coordinate screening programmes. The aim of this study was to assess the effect of screening and of the formation of the Registry on survival, incidence of CRC and age at onset of CRC, in FAP patients. Methods: Patients on the Manchester Polyposis Registry were categorised according to their mode of presentation; screening or symptomatic, and survival time from birth was calculated for each patient (n=353). The effect of the formation of the Registry was assessed by comparing survival times from birth for patients diagnosed in the 20 years before the establishment of the Registry, to patients diagnosed in the 20 years since the formation of the Registry (n=273). Results: This study demonstrated that survival was increased from 57.8 years to 70.4 years (p
    Original languageEnglish
    Pages (from-to)1378-1382
    Number of pages4
    JournalGut
    Volume59
    Issue number10
    DOIs
    Publication statusPublished - Oct 2010

    Fingerprint

    Dive into the research topics of 'The impact of screening and genetic registration on mortality and colorectal cancer incidence in familial adenomatous polyposis'. Together they form a unique fingerprint.

    Cite this