The in Vitro Osteogenic and Angiogenic Effects of Sodium-free Fluoride-containing Bioactive Glasses

Zhuo Lei; Fenghua Li; Xiaohui Chen; Fong-Ming Mo; Xiaojing Chen

doi:10.1016/j.matlet.2019.04.016

The in Vitro Osteogenic and Angiogenic Effects of Sodium-free Fluoride-containing Bioactive Glasses

Zhuo Lei, Fenghua Li, Xiaohui Chen, Fong-Ming Mo, Xiaojing Chen

Division of Dentistry (L5)

Central South University Of Technology

Research output: Contribution to journal › Article › peer-review

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Abstract

Fluoride is known to stimulate bone formation. Recently, novel sodium-free fluoride-containing bioactive glasses (FBGs) were found to be highly bioactive, dissolved in Tris and SBF buffer solutions releasing ions and promoting fluorapatite formation and offered great potential for medical and dental applications. However, there is very limited knowledge on the biological effects of these glasses, which are extremely important for clinical applications. This study investigated the bioactivity of FBGs and their osteogenic and angiogenic effects on MC3T3-E1 osteoblasts in α-MEM for the very first time. Results showed that these highly bioactive novel FBGs were non-cytotoxic. The addition of fluoride promoted mineralization, collagen formation, osteogenic and angiogenic genes expression in osteoblasts. Compared to sodium-containing BGs, a higher amount of fluoride can be incorporated into sodium-free BGs to improve glass biological effects.

Original language	English
Pages (from-to)	138-142
Journal	Materials Letters
Volume	248
Early online date	4 Apr 2019
DOIs	https://doi.org/10.1016/j.matlet.2019.04.016
Publication status	Published - 1 Aug 2019

Keywords

Amorphous materials
Biomaterials
Sodium-free
Fluoride
Osteogenesis
Angiogenesis

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10.1016/j.matlet.2019.04.016

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title = "The in Vitro Osteogenic and Angiogenic Effects of Sodium-free Fluoride-containing Bioactive Glasses",

abstract = "Fluoride is known to stimulate bone formation. Recently, novel sodium-free fluoride-containing bioactive glasses (FBGs) were found to be highly bioactive, dissolved in Tris and SBF buffer solutions releasing ions and promoting fluorapatite formation and offered great potential for medical and dental applications. However, there is very limited knowledge on the biological effects of these glasses, which are extremely important for clinical applications. This study investigated the bioactivity of FBGs and their osteogenic and angiogenic effects on MC3T3-E1 osteoblasts in α-MEM for the very first time. Results showed that these highly bioactive novel FBGs were non-cytotoxic. The addition of fluoride promoted mineralization, collagen formation, osteogenic and angiogenic genes expression in osteoblasts. Compared to sodium-containing BGs, a higher amount of fluoride can be incorporated into sodium-free BGs to improve glass biological effects.",

keywords = "Amorphous materials, Biomaterials, Sodium-free, Fluoride, Osteogenesis, Angiogenesis",

author = "Zhuo Lei and Fenghua Li and Xiaohui Chen and Fong-Ming Mo and Xiaojing Chen",

year = "2019",

month = aug,

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doi = "10.1016/j.matlet.2019.04.016",

language = "English",

volume = "248",

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journal = "Materials Letters",

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TY - JOUR

T1 - The in Vitro Osteogenic and Angiogenic Effects of Sodium-free Fluoride-containing Bioactive Glasses

AU - Lei, Zhuo

AU - Li, Fenghua

AU - Chen, Xiaohui

AU - Mo, Fong-Ming

AU - Chen, Xiaojing

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Fluoride is known to stimulate bone formation. Recently, novel sodium-free fluoride-containing bioactive glasses (FBGs) were found to be highly bioactive, dissolved in Tris and SBF buffer solutions releasing ions and promoting fluorapatite formation and offered great potential for medical and dental applications. However, there is very limited knowledge on the biological effects of these glasses, which are extremely important for clinical applications. This study investigated the bioactivity of FBGs and their osteogenic and angiogenic effects on MC3T3-E1 osteoblasts in α-MEM for the very first time. Results showed that these highly bioactive novel FBGs were non-cytotoxic. The addition of fluoride promoted mineralization, collagen formation, osteogenic and angiogenic genes expression in osteoblasts. Compared to sodium-containing BGs, a higher amount of fluoride can be incorporated into sodium-free BGs to improve glass biological effects.

AB - Fluoride is known to stimulate bone formation. Recently, novel sodium-free fluoride-containing bioactive glasses (FBGs) were found to be highly bioactive, dissolved in Tris and SBF buffer solutions releasing ions and promoting fluorapatite formation and offered great potential for medical and dental applications. However, there is very limited knowledge on the biological effects of these glasses, which are extremely important for clinical applications. This study investigated the bioactivity of FBGs and their osteogenic and angiogenic effects on MC3T3-E1 osteoblasts in α-MEM for the very first time. Results showed that these highly bioactive novel FBGs were non-cytotoxic. The addition of fluoride promoted mineralization, collagen formation, osteogenic and angiogenic genes expression in osteoblasts. Compared to sodium-containing BGs, a higher amount of fluoride can be incorporated into sodium-free BGs to improve glass biological effects.

KW - Amorphous materials

KW - Biomaterials

KW - Sodium-free

KW - Fluoride

KW - Osteogenesis

KW - Angiogenesis

U2 - 10.1016/j.matlet.2019.04.016

DO - 10.1016/j.matlet.2019.04.016

M3 - Article

SN - 0167-577X

VL - 248

SP - 138

EP - 142

JO - Materials Letters

JF - Materials Letters

ER -

The in Vitro Osteogenic and Angiogenic Effects of Sodium-free Fluoride-containing Bioactive Glasses

Abstract

Keywords

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