The influence of behavioural and psychological factors on medication adherence over time in rheumatoid arthritis patients: a study in the biologics era.

Catharine Morgan; John Mcbeth; Lis Cordingley; Kath Watson; Kimme L. Hyrich; Deborah P.M. Symmons; Ian N. Bruce

doi:10.1093/rheumatology/kev105

The influence of behavioural and psychological factors on medication adherence over time in rheumatoid arthritis patients: a study in the biologics era.

Catharine Morgan, John Mcbeth, Lis Cordingley, Kath Watson, Kimme L. Hyrich, Deborah P.M. Symmons, Ian N. Bruce

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To investigate the level of self-reported adherence to biologic treatment and establish the contribution of demographic, physical and psychological factors to biologic medication adherence in a rheumatoid arthritis cohort. Method: Adalimumab (ADA) treated patients were recruited through the British Society for Rheumatology Biologics Register – Rheumatoid Arthritis (BSRBR-RA) between May 2007 and April 2009. Demographic and baseline psychological measures including illness and medication beliefs with baseline and follow up measures of disease activity (DAS28), physical function (HAQ) and quality of life (SF36) at 6, 12 and 18 months were collected. Adherence was assessed at each follow up using the validated 19-item patient self-completed Compliance Questionnaire Rheumatology (CQR). Multi-level mixed effects modelling analysis was performed to investigate predictors of adherence. Results: Of the 329 ADA patients included, a quarter reported only moderate adherence (CQR score

Original language	English
Pages (from-to)	1780-1791
Number of pages	11
Journal	Rheumatology (Print)
Volume	54
Issue number	10
DOIs	https://doi.org/10.1093/rheumatology/kev105
Publication status	Published - 2015

Keywords

Rheumatoid Arthritis; Medication adherence; Biologic therapy; Illness perceptions; Medication beliefs; Epidemiology

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10.1093/rheumatology/kev105Licence: CC BY

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British Society for Rheumatology Rheumatoid Arthritis Register (BSRBR-RA)
Hyrich, K. (PI), Watson, K. (Support team), Mowbray, K. (Support team), Kearsley-Fleet, L. (CoI), Lunt, M. (CoI) & Verstappen, S. (CoI)
Project: Research
Arthritis Research UK Centre of Excellence in Epidemiology.
Symmons, D. (PI), Bruce, I. (CoI), Dixon, W. (CoI), Felson, D. (CoI), Hyrich, K. (CoI), Lunt, M. (CoI), Mcbeth, J. (CoI), O'Neill, T. (CoI) & Verstappen, S. (CoI)
1/08/13 → 31/07/18
Project: Research

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title = "The influence of behavioural and psychological factors on medication adherence over time in rheumatoid arthritis patients: a study in the biologics era.",

abstract = "Objective: To investigate the level of self-reported adherence to biologic treatment and establish the contribution of demographic, physical and psychological factors to biologic medication adherence in a rheumatoid arthritis cohort. Method: Adalimumab (ADA) treated patients were recruited through the British Society for Rheumatology Biologics Register – Rheumatoid Arthritis (BSRBR-RA) between May 2007 and April 2009. Demographic and baseline psychological measures including illness and medication beliefs with baseline and follow up measures of disease activity (DAS28), physical function (HAQ) and quality of life (SF36) at 6, 12 and 18 months were collected. Adherence was assessed at each follow up using the validated 19-item patient self-completed Compliance Questionnaire Rheumatology (CQR). Multi-level mixed effects modelling analysis was performed to investigate predictors of adherence. Results: Of the 329 ADA patients included, a quarter reported only moderate adherence (CQR score",

keywords = "Rheumatoid Arthritis; Medication adherence; Biologic therapy; Illness perceptions; Medication beliefs; Epidemiology",

author = "Catharine Morgan and John Mcbeth and Lis Cordingley and Kath Watson and Hyrich, {Kimme L.} and Symmons, {Deborah P.M.} and Bruce, {Ian N.}",

year = "2015",

doi = "10.1093/rheumatology/kev105",

language = "English",

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journal = "Rheumatology (Print)",

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T1 - The influence of behavioural and psychological factors on medication adherence over time in rheumatoid arthritis patients: a study in the biologics era.

AU - Morgan, Catharine

AU - Mcbeth, John

AU - Cordingley, Lis

AU - Watson, Kath

AU - Hyrich, Kimme L.

AU - Symmons, Deborah P.M.

AU - Bruce, Ian N.

PY - 2015

Y1 - 2015

N2 - Objective: To investigate the level of self-reported adherence to biologic treatment and establish the contribution of demographic, physical and psychological factors to biologic medication adherence in a rheumatoid arthritis cohort. Method: Adalimumab (ADA) treated patients were recruited through the British Society for Rheumatology Biologics Register – Rheumatoid Arthritis (BSRBR-RA) between May 2007 and April 2009. Demographic and baseline psychological measures including illness and medication beliefs with baseline and follow up measures of disease activity (DAS28), physical function (HAQ) and quality of life (SF36) at 6, 12 and 18 months were collected. Adherence was assessed at each follow up using the validated 19-item patient self-completed Compliance Questionnaire Rheumatology (CQR). Multi-level mixed effects modelling analysis was performed to investigate predictors of adherence. Results: Of the 329 ADA patients included, a quarter reported only moderate adherence (CQR score

AB - Objective: To investigate the level of self-reported adherence to biologic treatment and establish the contribution of demographic, physical and psychological factors to biologic medication adherence in a rheumatoid arthritis cohort. Method: Adalimumab (ADA) treated patients were recruited through the British Society for Rheumatology Biologics Register – Rheumatoid Arthritis (BSRBR-RA) between May 2007 and April 2009. Demographic and baseline psychological measures including illness and medication beliefs with baseline and follow up measures of disease activity (DAS28), physical function (HAQ) and quality of life (SF36) at 6, 12 and 18 months were collected. Adherence was assessed at each follow up using the validated 19-item patient self-completed Compliance Questionnaire Rheumatology (CQR). Multi-level mixed effects modelling analysis was performed to investigate predictors of adherence. Results: Of the 329 ADA patients included, a quarter reported only moderate adherence (CQR score

KW - Rheumatoid Arthritis; Medication adherence; Biologic therapy; Illness perceptions; Medication beliefs; Epidemiology

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DO - 10.1093/rheumatology/kev105

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The influence of behavioural and psychological factors on medication adherence over time in rheumatoid arthritis patients: a study in the biologics era.

Abstract

Keywords

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Projects

British Society for Rheumatology Rheumatoid Arthritis Register (BSRBR-RA)

Arthritis Research UK Centre of Excellence in Epidemiology.

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